Academic Journal
Characterization of Disordered Biomolecular Systems with Scattering Techniques: A Flexible Protein Complex and Solid-Supported Lipid Bilayers ...
| العنوان: | Characterization of Disordered Biomolecular Systems with Scattering Techniques: A Flexible Protein Complex and Solid-Supported Lipid Bilayers ... |
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| المؤلفون: | Michalak, Dennis |
| بيانات النشر: | Carnegie Mellon University |
| سنة النشر: | 2022 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | 29901 Biological Physics, FOS: Biological sciences |
| الوصف: | Disorder serves a functional role in cellular membranes and flexible protein domains. An in-plane fluid mixture of phospholipids, carbohydrates, membrane proteins, andmore constitute the plasma membrane. Disordered regions of proteins leverage a wide conformational space to facilitate complexation, signaling, and regulatory interactions.Experimental approaches which quantify structural information of these systems ideally facilitate biomimetic sample environments. Scattering techniques provide a minimally restrictive platform for characterizing macromolecular systems including lipid bilayers and intrinsically disordered proteins. This thesis contains studies of these systems which utilize X-ray and neutron scattering methods complemented by computational and theoretical structural predictions. The small GTPase KRas acts as a binary switch at the plasma membrane, anchored by a flexible domain, participating in signaling pathways vital for cellular survival and proliferation. Its localization to the plasma ... |
| نوع الوثيقة: | text thesis |
| اللغة: | unknown |
| Relation: | https://dx.doi.org/10.1184/r1/18427241 |
| DOI: | 10.1184/r1/18427241.v1 |
| الاتاحة: | https://dx.doi.org/10.1184/r1/18427241.v1 https://kilthub.cmu.edu/articles/thesis/Characterization_of_Disordered_Biomolecular_Systems_with_Scattering_Techniques_A_Flexible_Protein_Complex_and_Solid-Supported_Lipid_Bilayers/18427241/1 |
| Rights: | Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode ; cc-by-4.0 |
| رقم الانضمام: | edsbas.A7B82405 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1184/r1/18427241.v1 |
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