Academic Journal
Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury
| العنوان: | Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury |
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| المؤلفون: | Korkmaz, Filiz T, Shenoy, Anukul T, Symer, Elise M, Baird, Lillia A, Odom, Christine V, Arafa, Emad I, Dimbo, Ernest L, Na, Elim, Molina-Arocho, William, Brudner, Matthew, Standiford, Theodore J, Mehta, Jawahar L, Sawamura, Tatsuya, Jones, Matthew R, Mizgerd, Joseph P, Traber, Katrina E, Quinton, Lee J |
| المساهمون: | Medicine |
| المصدر: | JCI insight ; 7 ; 23 ; United States |
| سنة النشر: | 2024 |
| المجموعة: | University of Massachusetts, Medical School: eScholarship@UMMS |
| مصطلحات موضوعية: | Bacterial infections, Cellular immune response, Immunology, Inflammation, Innate immunity |
| الوصف: | Identifying host factors that contribute to pneumonia incidence and severity are of utmost importance to guiding the development of more effective therapies. Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1, encoded by OLR1) is a scavenger receptor known to promote vascular injury and inflammation, but whether and how LOX-1 functions in the lung are unknown. Here, we provide evidence of substantial accumulation of LOX-1 in the lungs of patients with acute respiratory distress syndrome and in mice with pneumonia. Unlike previously described injurious contributions of LOX-1, we found that LOX-1 is uniquely protective in the pulmonary airspaces, limiting proteinaceous edema and inflammation. We also identified alveolar macrophages and recruited neutrophils as 2 prominent sites of LOX-1 expression in the lungs, whereby macrophages are capable of further induction during pneumonia and neutrophils exhibit a rapid, but heterogenous, elevation of LOX-1 in the infected lung. Blockade of LOX-1 led to dysregulated immune signaling in alveolar macrophages, marked by alterations in activation markers and a concomitant elevation of inflammatory gene networks. However, bone marrow chimeras also suggested a prominent role for neutrophils in LOX-1-mediated lung protection, further supported by LOX-1+ neutrophils exhibiting transcriptional changes consistent with reparative processes. Taken together, this work establishes LOX-1 as a tissue-protective factor in the lungs during pneumonia, possibly mediated by its influence on immune signaling in alveolar macrophages and LOX-1+ airspace neutrophils. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2379-3708 |
| Relation: | JCI Insight; https://doi.org/10.1172/jci.insight.149955; Korkmaz FT, Shenoy AT, Symer EM, Baird LA, Odom CV, Arafa EI, Dimbo EL, Na E, Molina-Arocho W, Brudner M, Standiford TJ, Mehta JL, Sawamura T, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. JCI Insight. 2022 Dec 8;7(23):e149955. doi:10.1172/jci.insight.149955. PMID: 36264633; PMCID: PMC9746901.; http://hdl.handle.net/20.500.14038/53306 |
| DOI: | 10.1172/jci.insight.149955 |
| الاتاحة: | https://doi.org/10.1172/jci.insight.149955 https://hdl.handle.net/20.500.14038/53306 |
| Rights: | Copyright: © 2022, Korkmaz et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. ; Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.A7B5FD8D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23793708 |
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| DOI: | 10.1172/jci.insight.149955 |