Academic Journal
Autoantibody profile and clinical characteristics in a cohort of Chinese adult myasthenia gravis patients
| العنوان: | Autoantibody profile and clinical characteristics in a cohort of Chinese adult myasthenia gravis patients |
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| المؤلفون: | Hong, Yu, Li, Hai-Feng, Skeie, Geir Olve, Romi, Fredrik, Hao, Hong-Jun, Zhang, Xu, Gao, Xiang, Owe, Jone Furlund, Gilhus, Nils Erik |
| المساهمون: | Gilhus, NE (reprint author), Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway., Univ Bergen, Dept Clin Med, Bergen, Norway., Shandong Univ, Qilu Hosp, Dept Neurol, Jinan, Peoples R China., Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway., Peking Univ, Hosp 1, Dept Neurol, Beijing, Peoples R China., Qingdao Univ, Affiliated Hosp, Dept Neurol, Qingdao, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | JOURNAL OF NEUROIMMUNOLOGY |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Myasthenia gravis, Thymoma, Titin antibodies, Ryanodine receptor antibodies, Muscle-specific kinase antibodies, RECEPTOR ANTIBODIES, ONSET, ASSOCIATION, POPULATION, TITIN, SERUM |
| الوصف: | Myasthenia gravis (MG) is an autoimmune disorder with heterogeneity. Antibodies against acetylcholine receptor (AChR), muscle-specific kinase (MuSK), titin and ryanodine receptor (RyR) were examined in 437 adult Chinese MG patients. The AChR, MuSK, titin and RyR antibodies were found in 82.2%, 2.3%, 28.4% and 23.8% of all patients. Autoantibody profiles vary among different MG subgroups. Thymoma MG patients had high frequencies of AChR (99.2%), titin (50.8%) and RyR antibodies (46.9%).The titin and RyR antibodies also showed high frequencies in late onset patients (54.4% and 33.3%, respectively). These two antibodies may indicate an underlying thymoma when combined. The patients with titin and RyR antibodies tend to have more severe disease and worse outcome, and may need more active immunosuppressive treatment. (C) 2016 Elsevier B.V. All rights reserved. ; Torbjorg Hauges' Legacy; National Natural Science Foundation of China [81070963]; Natural Science Foundation of Shandong Province [ZR2010HM019] ; SCI(E) ; PubMed ; ARTICLE ; nils.gilhus@helse-bergen.no ; 51-57 ; 298 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0165-5728 1872-8421 |
| Relation: | JOURNAL OF NEUROIMMUNOLOGY.2016,298,51-57.; 1438338; http://hdl.handle.net/20.500.11897/492957; WOS:000383936600008 |
| DOI: | 10.1016/j.jneuroim.2016.07.001 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/492957 https://doi.org/10.1016/j.jneuroim.2016.07.001 |
| رقم الانضمام: | edsbas.A7AAB078 |
| قاعدة البيانات: | BASE |
| تدمد: | 01655728 18728421 |
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| DOI: | 10.1016/j.jneuroim.2016.07.001 |