Academic Journal
Prevalence of diabetes among children treated with growth hormone in Israel
| العنوان: | Prevalence of diabetes among children treated with growth hormone in Israel |
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| المؤلفون: | Lutski, M., Zucker, I., Zadik, Z., Libruder, C., Blumenfeld, O., Shohat, T., Laron, Z. |
| المصدر: | Diabetic Medicine ; volume 36, issue 10, page 1276-1281 ; ISSN 0742-3071 1464-5491 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aims To determine the long‐term risk of diabetes in a cohort of children treated with recombinant human growth hormone in Israel, using data from the Israeli National Diabetes Register. Methods Between 1988 and 2009, 2513 children were approved for growth hormone treatment. They were assigned to one of two groups. The first group included children treated for isolated growth hormone deficiency and who were small for gestational age and the second included those treated for multiple pituitary hormone deficiency, chronic renal failure, Turner syndrome or Prader–Willi syndrome. The cohort was cross‐linked with the Israeli National Diabetes Register for 2014 (mean follow‐up duration 12.1±5.3 years), and prevalent cases of diabetes were identified. Standardized prevalence ratios for diabetes were calculated for people aged 10–29 years. Results In 2014, a total of 23 individuals were identified with diabetes (four with pre‐existing diabetes, seven developed diabetes before age 17 years and 12 developed it at a later age). In the isolated growth hormone deficiency and small‐for‐gestational‐age group there was no difference in the prevalence of diabetes compared with the general population (standardized prevalence ratio 2.05, 95% CI 0.94–3.89). In the group that included people with multiple pituitary hormone deficiency, chronic renal failure, Turner syndrome and Prader–Willi syndrome there was a significantly higher diabetes prevalence (standardized prevalence ratio 11.94, 95% CI 6.53–20.00) compared with the general population. Conclusions No difference in diabetes prevalence was found in the isolated growth hormone deficiency and small‐for‐gestational‐age group, compared with the general population. Children treated with growth hormone with pre‐existing risk factors had an increased prevalence of diabetes. It is advisable to monitor blood glucose levels closely during and after growth hormone treatment, especially in such children. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/dme.13910 |
| الاتاحة: | http://dx.doi.org/10.1111/dme.13910 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fdme.13910 https://onlinelibrary.wiley.com/doi/pdf/10.1111/dme.13910 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/dme.13910 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.A73E13D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/dme.13910 |
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