Academic Journal
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV
| العنوان: | Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV |
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| المؤلفون: | Stacey, Maria A., Marsden, Morgan, Pham N., Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M., Taylor, Philip R., Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W. G., Humphreys, Ian R. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2014 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| مصطلحات موضوعية: | R Medicine (General) |
| الوصف: | During primary infection, murine cytomegalovirus (MCMV) spreads systemically, resulting in virus replication and pathology in multiple organs. This disseminated infection is ultimately controlled, but the underlying immune defense mechanisms are unclear. Investigating the role of the cytokine IL-22 in MCMV infection, we discovered an unanticipated function for neutrophils as potent antiviral effector cells that restrict viral replication and associated pathogenesis in peripheral organs. NK-, NKT-, and T cell-secreted IL-22 orchestrated antiviral neutrophil-mediated responses via induction in stromal nonhematopoietic tissue of the neutrophil-recruiting chemokine CXCL1. The antiviral effector properties of infiltrating neutrophils were directly linked to the expression of TNF-related apoptosis-inducing ligand (TRAIL). Our data identify a role for neutrophils in antiviral defense, and establish a functional link between IL-22 and the control of antiviral neutrophil responses that prevents pathogenic herpesvirus infection in peripheral organs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/60454/1/WOA-20132014-08.pdf; Stacey, Maria A., Marsden, Morgan https://orca.cardiff.ac.uk/view/cardiffauthors/A127755M.html, Pham N., Tu Anh, Clare, Simon, Dolton, Garry https://orca.cardiff.ac.uk/view/cardiffauthors/A0385695.html, Stack, Gabrielle, Jones, Emma https://orca.cardiff.ac.uk/view/cardiffauthors/A109363C.html, Klenerman, Paul, Gallimore, Awen M. https://orca.cardiff.ac.uk/view/cardiffauthors/A0161259.html orcid:0000-0001-6675-7004 orcid:0000-0001-6675-7004, Taylor, Philip R. https://orca.cardiff.ac.uk/view/cardiffauthors/A101858K.html orcid:0000-0003-0163-1421 orcid:0000-0003-0163-1421, Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A. https://orca.cardiff.ac.uk/view/cardiffauthors/A109363C.html, Wilkinson, Gavin W. G. https://orca.cardiff.ac.uk/view/cardiffauthors/A047014M.html orcid:0000-0002-5623-0126 orcid:0000-0002-5623-0126 and Humphreys, Ian R. https://orca.cardiff.ac.uk/view/cardiffauthors/A1077626.html orcid:0000-0002-9512-5337 orcid:0000-0002-9512-5337 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4) , pp. 471-483. 10.1016/j.chom.2014.03.003 https://doi.org/10.1016/j.chom.2014.03.003 file https://orca.cardiff.ac.uk/id/eprint/60454/1/WOA-20132014-08.pdf |
| DOI: | 10.1016/j.chom.2014.03.003 |
| الاتاحة: | https://orca.cardiff.ac.uk/id/eprint/60454/ https://doi.org/10.1016/j.chom.2014.03.003 https://orca.cardiff.ac.uk/id/eprint/60454/1/WOA-20132014-08.pdf |
| Rights: | cc_by |
| رقم الانضمام: | edsbas.A729297A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.chom.2014.03.003 |
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