Academic Journal
Efficacy of Long-Term Remote Ischemic Conditioning on Vascular and Neuronal Function in Type 2 Diabetes Patients With Peripheral Arterial Disease
| العنوان: | Efficacy of Long-Term Remote Ischemic Conditioning on Vascular and Neuronal Function in Type 2 Diabetes Patients With Peripheral Arterial Disease |
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| المؤلفون: | Hansen, Christian S., Jørgensen, Marit E., Fleischer, Jesper, Bøtker, Hans Erik, Rossing, Peter |
| المصدر: | Hansen , C S , Jørgensen , M E , Fleischer , J , Bøtker , H E & Rossing , P 2019 , ' Efficacy of Long-Term Remote Ischemic Conditioning on Vascular and Neuronal Function in Type 2 Diabetes Patients With Peripheral Arterial Disease ' , Journal of the American Heart Association , vol. 8 , no. 13 , e011779 . https://doi.org/10.1161/JAHA.118.011779 |
| سنة النشر: | 2019 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | diabetes mellitus, nerve function, nervous system, peripheral vascular disease, remote ischemic conditioning, vascular function |
| الوصف: | Background Peripheral artery disease is a major socioeconomic challenge in the diabetes mellitus community and non-surgical treatment options are limited. As remote ischemic conditioning ( RIC ) improves vascular function and attenuates ischemia-induced tissue damage, we investigated the efficacy of RIC on vascular and neuronal function in type 2 diabetes mellitus patients with peripheral artery disease. Methods and Results We enrolled 36 type 2 diabetes mellitus patients with moderately reduced toe pressure (40-70 mm Hg) in a randomized sham-controlled double-masked trial. Patients were allocated to 12 weeks once daily upper arm cuff-based treatment of either RIC treatment (4 cycles of 5-minute ischemia followed by 5-minute reperfusion) or similar sham-device treatment. Primary outcome was transcutaneous tissue oxygen tension of the instep of the feet. Secondary outcomes were aortic pulse wave velocity, toe pressure and toe-brachial index. Tertiary outcomes were markers of peripheral and autonomic nerve function. We enrolled 36 patients (83% men). Patients had a mean ( SD ) age of 70.7 years (6.8), diabetes mellitus duration of 18.4 years (8.3), HbA1c (gycated hemoglobin) of 59.7 mmol/mol (11.2). Eighty percent had peripheral symmetrical neuropathy. The mean difference in change of transcutaneous tissue oxygen tension from baseline between the RIC and sham-treated groups was -0.03 mm Hg ([95% CI -0.1; 0.04], P=0.438). RIC did not elicit any change in additional outcomes. Three patients experienced transient skin petechiae in the treated arm. Conclusions Long-term repeated remote ischemic conditioning treatment have no effect on tissue oxygenation, vascular or neuronal function in patients with type 2 diabetes mellitus and moderate peripheral artery disease. Clinical Trial Registration URL : http://www.ClinicalTrials.gov . Unique identifier: NCT02749942. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://portal.findresearcher.sdu.dk/da/publications/3e200bd4-9d3e-4e9b-b345-f3127ad13dc2 |
| DOI: | 10.1161/JAHA.118.011779 |
| الاتاحة: | https://portal.findresearcher.sdu.dk/da/publications/3e200bd4-9d3e-4e9b-b345-f3127ad13dc2 https://doi.org/10.1161/JAHA.118.011779 https://findresearcher.sdu.dk/ws/files/152599713/Efficacy_of_Long_Term_Remote_Ischemic_Conditioning.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A70FF2B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/JAHA.118.011779 |
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