Academic Journal
Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin**
| العنوان: | Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin** |
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| المؤلفون: | Couturier, Cédric, Groß, Sebastian, von Tesmar, Alexander, Hoffmann, Judith, Deckarm, Selina, Fievet, Anouchka, Dubarry, Nelly, Taillier, Thomas, Pöverlein, Christoph, Stump, Heike, Kurz, Michael, Toti, Luigi, Haag Richter, Sabine, Schummer, Dietmar, Sizun, Philippe, Hoffmann, Michael, Prasad Awal, Ram, Zaburannyi, Nestor, Harmrolfs, Kirsten, Wink, Joachim, Lessoud, Emilie, Vermat, Thierry, Cazals, Veronique, Silve, Sandra, Bauer, Armin, Mourez, Michael, Fraisse, Laurent, Leroi‐Geissler, Corinne, Rey, Astrid, Versluys, Stéphanie, Bacqué, Eric, Müller, Rolf, Renard, Stephane |
| المصدر: | Angewandte Chemie International Edition ; volume 61, issue 51 ; ISSN 1433-7851 1521-3773 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides . The linear peptide structure contains an unprecedented (2 R ,3 S )‐γ‐ N ‐methyl‐β‐hydroxy‐histidine moiety. Corramycin exhibits anti‐Gram‐negative activity against Escherichia coli ( E. coli ) and is taken up via two transporter systems, SbmA and YejABEF. Furthermore, the Corramycin biosynthetic gene cluster (BGC) was identified and a biosynthesis model was proposed involving a 12‐modular non‐ribosomal peptide synthetase/polyketide synthase. Bioinformatic analysis of the BGC combined with the development of a total synthesis route allowed for the elucidation of the molecule's absolute configuration. Importantly, intravenous administration of 20 mg kg −1 of Corramycin in an E. coli mouse infection model resulted in 100 % survival of animals without toxic side effects. Corramycin is thus a promising starting point to develop a potent antibacterial drug against hospital‐acquired infections. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/anie.202210747 |
| الاتاحة: | http://dx.doi.org/10.1002/anie.202210747 https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202210747 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.202210747 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.A69628B9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/anie.202210747 |
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