Academic Journal
Repetitive Transcranial Magnetic Stimulation Promotes Rapid Psychiatric Stabilization in Acutely Suicidal Military Service Members
| العنوان: | Repetitive Transcranial Magnetic Stimulation Promotes Rapid Psychiatric Stabilization in Acutely Suicidal Military Service Members |
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| المؤلفون: | Hines, Christopher E., Mooney, Scott, Watson, Nora L., Looney, Stephen W., Wilkie, David J. |
| المصدر: | The Journal of ECT ; volume 38, issue 2, page 103-109 ; ISSN 1533-4112 1095-0680 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2022 |
| الوصف: | Objective This study presents data for using accelerated transcranial magnetic stimulation (TMS) as an intervention for suicidal crisis (SC). Methods This prospective, single-site, randomized, double-blind trial enrolled active-duty military participants with SC to receive either active TMS (n = 59) or sham TMS (n = 61) 3 times per day for 3 consecutive days. Our primary outcome, the Beck Scale for Suicidal Ideation—current (SSI-C), was measured before each session of TMS. Secondary outcomes measured both the SSI-C and the Beck Scale for Suicidal Ideation—total daily for the 3 intervention days and at 1, 3, and 6 months of follow-up. Results In the modified intention to treat (mITT) analysis of SSI-C changes over treatment sessions, the TMS active group had accelerated decline in suicidal ideation as compared with sham: β for interaction was 0.12 points greater SSI-C decline per session (standard error [SE], 0.06) in TMS versus sham ( P = 0.04). In both the mITT and per-protocol active TMS groups, the mean final SSI-C scores were below 3. These scores remained below 3 for the entire 6-month follow-up period. Conclusions In this military trial of suicidal patients, we found that both active and sham accelerated TMS rapidly reduces SC. Moreover, in the mITT analysis, there was a statistically significant antisuicidal benefit of active TMS versus sham TMS in the primary outcome. Both the mITT and per-protocol groups moved from higher to approximately 7 times lower suicide risk strata and remained there for the duration of the study. Further studies are warranted to understand accelerated TMS' full potential as a treatment for SC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/yct.0000000000000810 |
| DOI: | 10.1097/YCT.0000000000000810 |
| الاتاحة: | http://dx.doi.org/10.1097/yct.0000000000000810 https://journals.lww.com/10.1097/YCT.0000000000000810 |
| رقم الانضمام: | edsbas.A6765929 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/yct.0000000000000810 |
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