Academic Journal
Four Undescribed compounds Isolated from the Aerial Parts of Phyllanthus cochinchinensis with Antimicrobial Activity and NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells
| العنوان: | Four Undescribed compounds Isolated from the Aerial Parts of Phyllanthus cochinchinensis with Antimicrobial Activity and NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells |
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| المؤلفون: | Yen, Duong Thi Hai, Hang, Dan Thi Thuy, Yen, Pham Hai, Tai, Bui Huu, Dung, Duong Thi, Huong, Phan Thi Thanh, Dung, Nguyen Viet, Trang, Do Thi, Bang, Ngo Anh, Mai, Nguyen Thi, Kiem, Phan Van |
| المساهمون: | Vietnam Academy of Science and Technology |
| المصدر: | Chemistry & Biodiversity ; volume 21, issue 3 ; ISSN 1612-1872 1612-1880 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Four previously undescribed compounds named phyllancosides A and B ( 1 and 2 ), and phyllancochines A and B ( 3 and 4 ) together with ten known compounds ( 5 ‐ 14 ) were isolated from the aerial parts of Phyllanthus cochinchinensis Spreng. Their chemical structures were elucidated on the basis of comprehensive analysis of IR, HR‐ESI‐MS, 1D and 2D NMR spectra. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD) spectra. Compounds 3 , 4 , and 10 showed antimicrobial activity against E. faecalis , S. aureus , and B. cereus with the MIC values in range of 32–256 μg/mL. Compound 11 inhibited E. faecalis and B. cereus , and 7 inhibited S. aureus with the MIC values in range of 64–128 μg/mL. In addition, compounds 1 , 3 , 4 , 8 , and 9 showed significantly NO production inhibitory activity in LPS activated RAW 264.7 cells with IC 50 values ranging from 36.57 to 56.34 μM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cbdv.202302105 |
| الاتاحة: | http://dx.doi.org/10.1002/cbdv.202302105 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202302105 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.A6231CCF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cbdv.202302105 |
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