Academic Journal
Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells
| العنوان: | Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells |
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| المؤلفون: | Mesbahi, Y, Trahair, TN, Lock, RB, Connerty, P |
| المصدر: | urn:ISSN:2234-943X ; Frontiers in Oncology, 12, 807266 |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | Stem Cell Research, Rare Diseases, Cancer, Stem Cell Research - Nonembryonic - Non-Human, Pediatric Research Initiative, Hematology, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, 2 Aetiology, acute myeloid leukaemia, cancer metabolism, leukaemic stem cells, metabolic plasticity, metabolic targeting, anzsrc-for: 1112 Oncology and Carcinogenesis |
| الوصف: | Despite intensive chemotherapy regimens, up to 60% of adults with acute myeloid leukaemia (AML) will relapse and eventually succumb to their disease. Recent studies suggest that leukaemic stem cells (LSCs) drive AML relapse by residing in the bone marrow niche and adapting their metabolic profile. Metabolic adaptation and LSC plasticity are novel hallmarks of leukemogenesis that provide important biological processes required for tumour initiation, progression and therapeutic responses. These findings highlight the importance of targeting metabolic pathways in leukaemia biology which might serve as the Achilles’ heel for the treatment of AML relapse. In this review, we highlight the metabolic differences between normal haematopoietic cells, bulk AML cells and LSCs. Specifically, we focus on four major metabolic pathways dysregulated in AML; (i) glycolysis; (ii) mitochondrial metabolism; (iii) amino acid metabolism; and (iv) lipid metabolism. We then outline established and emerging drug interventions that exploit metabolic dependencies of leukaemic cells in the treatment of AML. The metabolic signature of AML cells alters during different biological conditions such as chemotherapy and quiescence. Therefore, targeting the metabolic vulnerabilities of these cells might selectively eradicate them and improve the overall survival of patients with AML. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | http://purl.org/au-research/grants/nhmrc/APP1059804; http://purl.org/au-research/grants/nhmrc/APP1157871; http://hdl.handle.net/1959.4/unsworks_80143; https://unsworks.unsw.edu.au/bitstreams/629f23dd-a37a-41b7-ac8e-e1750c401d0a/download; https://doi.org/10.3389/fonc.2022.807266 |
| DOI: | 10.3389/fonc.2022.807266 |
| الاتاحة: | http://hdl.handle.net/1959.4/unsworks_80143 https://unsworks.unsw.edu.au/bitstreams/629f23dd-a37a-41b7-ac8e-e1750c401d0a/download https://doi.org/10.3389/fonc.2022.807266 |
| Rights: | open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read ; This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms |
| رقم الانضمام: | edsbas.A5FDA54 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2022.807266 |
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