Academic Journal
Factors affecting high-density lipoprotein cholesterol in HIV-infected patients on nevirapine-based antiretroviral therapy
| العنوان: | Factors affecting high-density lipoprotein cholesterol in HIV-infected patients on nevirapine-based antiretroviral therapy |
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| المؤلفون: | C Padmapriyadarsini, K Ramesh, L Sekar, Geetha Ramachandran, Devaraj Reddy, G Narendran, S Sekar, C Chandrasekar, D Anbarasu, Christine Wanke, Soumya Swaminathan |
| المصدر: | Indian Journal of Medical Research, Vol 145, Iss 5, Pp 641-650 (2017) |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Antiretroviral therapy - body mass index - gene polymorphisms - high-density lipoprotein-cholesterol - HIV - nevirapine - viral load, Medicine |
| الوصف: | Background & objectives: Cardiovascular disease (CVD) risk with low high-density lipoprotein cholesterol (HDL-C) and high triglycerides is common in the general population in India. As nevirapine (NVP)-based antiretroviral therapy (ART) tends to increase HDL-C, gene polymorphisms associated with HDL-C metabolism in HIV-infected adults on stable NVP-based ART were studied. Methods: A cross-sectional study was conducted between January 2013 and July 2014 among adults receiving NVP-based ART for 12-15 months. Blood lipids were estimated and gene polymorphisms in apolipoprotein C3 (APOC3), cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL) genes were analyzed by real-time polymerase chain reaction. Framingham's 10-yr CVD risk score was estimated. Logistic regression was done to show factors related to low HDL-C levels. Results: Of the 300 patients included (mean age: 38.6±8.7 yr; mean CD4 count 449±210 cell/μl), total cholesterol (TC) >200 mg/dl was observed in 116 (39%) patients. Thirty nine per cent males and 47 per cent females had HDL-C levels below normal while 32 per cent males and 37 per cent females had TC/HDL ratio of 4.5 and 4.0, respectively. Body mass index [adjusted odds ratio (aOR)=1.70, 95% confidence interval (CI) 1.01-2.84, P=0.04] and viral load (aOR=3.39, 95% CI: 1.52-7.52, P=0.003) were negatively associated with serum HDL-C levels. The 10-yr risk score of developing CVD was 11-20 per cent in 3 per cent patients. Allelic variants of APOC3 showed a trend towards low HDL-C. Interpretation & conclusions: High-risk lipid profiles for atherosclerosis and cardiovascular disease were common among HIV-infected individuals, even after 12 months of NVP-based ART. Targeted interventions to address these factors should be recommended in the national ART programmes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0971-5916 |
| Relation: | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=145;issue=5;spage=641;epage=650;aulast=Padmapriyadarsini; https://doaj.org/toc/0971-5916; https://doaj.org/article/5c276815c9bb41189e2c91921157d0ff |
| DOI: | 10.4103/ijmr.IJMR_1611_15 |
| الاتاحة: | https://doi.org/10.4103/ijmr.IJMR_1611_15 https://doaj.org/article/5c276815c9bb41189e2c91921157d0ff |
| رقم الانضمام: | edsbas.A5A25E19 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09715916 |
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| DOI: | 10.4103/ijmr.IJMR_1611_15 |