Academic Journal
The investigation of the effects of monosodium glutamate on healthy rats and rats with STZ‐induced diabetes
| العنوان: | The investigation of the effects of monosodium glutamate on healthy rats and rats with STZ‐induced diabetes |
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| المؤلفون: | Urcar Gelen, Sevda, Ozkanlar, Seckin, Gedikli, Semin, Atasever, Mustafa |
| المصدر: | Journal of Biochemical and Molecular Toxicology ; volume 38, issue 1 ; ISSN 1095-6670 1099-0461 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Monosodium glutamate (MSG, E621) is a flavor‐enhancing food additive used widely in the food preparation industry and consumed regularly. It is considered that long‐term consumption of MSG causes metabolic syndrome and obesity. Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood sugar, polyuria, polydipsia, and polyphagia, in which insulin secreted from pancreatic β cells is inadequate for maintaining blood glucose homeostasis. Rats were application 65 mg/kg streptozotocin (STZ) solution intraperitoneally and a diabetes model was created. For this purpose, freshly prepared STZ was injected into the peritoneum. Tumor necrosis factor‐α, interleukin (IL)‐10, IL‐6, and IL‐1β levels in STZ, MSG, and STZ + MSG groups were found to be significantly increased in inflammation parameters measured on the 28th day of administration when compared to the Control Group ( p < 0.001). Also, although malondialdehyde (MDA) levels increased significantly in the STZ + MSG group when compared to the control group ( p < 0.001), glutathione (GSH), and superoxide dismutase (SOD) levels were significantly decreased in the STZ, MSG, and STZ + MSG groups when compared to the control group ( p < 0.001). Also, although glucose levels increased significantly in STZ and STZ + MSG at the end of the 28th day ( p < 0.01), insulin levels decreased in STZ, MSG, and STZ + MSG groups when compared to the control groups ( p < 0.01). As a result, it was found that STZ and MSG application significantly increased cytokine production, increased MDA, which is an oxidant parameter in pancreatic tissue, and decreased antioxidants (GSH and SOD) when compared to the control groups. It was also found that MSG disrupted the normal histological structure in pancreatic cells, and the damage was much more in both exocrine and endocrine pancreatic areas in the STZ + MSG group when compared to the STZ and MSG groups. It was considered that with the increased use of MSG, the susceptibility to DM might increase ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jbt.23612 |
| الاتاحة: | http://dx.doi.org/10.1002/jbt.23612 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbt.23612 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.A56E2BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jbt.23612 |
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