Academic Journal
Women who carry a fragile X premutation are biologically older than noncarriers as measured by telomere length
| العنوان: | Women who carry a fragile X premutation are biologically older than noncarriers as measured by telomere length |
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| المؤلفون: | Albizua, Igor, Rambo‐Martin, Benjamin L., Allen, Emily G., He, Weiya, Amin, Ashima S., Sherman, Stephanie L. |
| المساهمون: | Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Neurological Disorders and Stroke |
| المصدر: | American Journal of Medical Genetics Part A ; volume 173, issue 11, page 2985-2994 ; ISSN 1552-4825 1552-4833 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Women who carry a fragile X premutation, defined as having 55–200 unmethylated CGG repeats in the 5′ UTR of the X‐linked FMR1 gene, have a 20‐fold increased risk for primary ovarian insufficiency (FXPOI). We tested the hypothesis that women with a premutation + FXPOI have shorter telomeres than those without FXPOI because they are “biologically older.” Using linear regression, we found that women carrying a premutation ( n = 172) have shorter telomeres and hence, are “biologically older” than women carrying the normal size allele ( n = 81). Strikingly, despite having shorter telomeres, age was not statistically associated with their telomere length, in contrast to non‐carrier controls. Further, telomere length within premutation carriers was not associated with repeat length but was associated with a diagnosis of FXPOI, although the latter finding may depend on FXPOI age of onset. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ajmg.a.38476 |
| الاتاحة: | http://dx.doi.org/10.1002/ajmg.a.38476 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.a.38476 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.a.38476 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.A563A271 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ajmg.a.38476 |
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