Academic Journal
Do NSm Virulence Factors in the Bunyavirales Viral Order Originate from Gn Gene Duplication?
| العنوان: | Do NSm Virulence Factors in the Bunyavirales Viral Order Originate from Gn Gene Duplication? |
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| المؤلفون: | Victor Lefebvre, Ravy Leon Foun Lin, Laura Cole, François-Loïc Cosset, Marie-Laure Fogeron, Anja Böckmann |
| المصدر: | Viruses, Vol 16, Iss 1, p 90 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Bunyavirales, virulence factor, NSm, AlphaFold, structure, Microbiology, QR1-502 |
| الوصف: | One-third of the nine WHO shortlisted pathogens prioritized for research and development in public health emergencies belong to the Bunyavirales order. Several Bunyavirales species carry an NSm protein that acts as a virulence factor. We predicted the structures of these NSm proteins and unexpectedly found that in two families, their cytosolic domain was inferred to have a similar fold to that of the cytosolic domain of the viral envelope-forming glycoprotein N (Gn cyto ) encoded on the same genome fragment. We show that although the sequence identity between the NSm cyto and the Gn cyto domains is low, the conservation of the two zinc finger-forming CysCysHisCys motifs explains the predicted structural conservation. Importantly, our predictions provide a first glimpse into the long-unknown structure of NSm. Also, these predictions suggest that NSm is the result of a gene duplication event in the Bunyavirales Nairoviridae and Peribunyaviridae families and that such events may be common in the recent evolutionary history of RNA viruses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1999-4915 |
| Relation: | https://www.mdpi.com/1999-4915/16/1/90; https://doaj.org/toc/1999-4915; https://doaj.org/article/1a2a74f11a024e0f92fb54cd1cf360e6 |
| DOI: | 10.3390/v16010090 |
| الاتاحة: | https://doi.org/10.3390/v16010090 https://doaj.org/article/1a2a74f11a024e0f92fb54cd1cf360e6 |
| رقم الانضمام: | edsbas.A545E1FA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19994915 |
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| DOI: | 10.3390/v16010090 |