Academic Journal
Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration
| العنوان: | Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration |
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| المؤلفون: | Banella, C, Ginevrino, M, Catalano, G, Fabiani, E, Falconi, G, Divona, M, Curzi, P, Panetta, P, Voso, M T, Noguera, N I |
| المساهمون: | Banella, C, Ginevrino, M, Catalano, G, Fabiani, E, Falconi, G, Divona, M, Curzi, P, Panetta, P, Voso, Mt, Noguera, Ni |
| بيانات النشر: | Elsevier SA |
| سنة النشر: | 2020 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Acute myeloid leukemia, Aneuploidy, FGFR3–TACC3, Glioblastoma, Myelodysplastic syndromes, Settore MED/15 - MALATTIE DEL SANGUE |
| الوصف: | FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3-TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32199932; volume:-; issue:-; firstpage:1; lastpage:6; numberofpages:6; journal:HEMATOLOGY/ONCOLOGY AND STEM CELL THERAPY; http://hdl.handle.net/2108/257121; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85082087376 |
| DOI: | 10.1016/j.hemonc.2020.02.005 |
| الاتاحة: | http://hdl.handle.net/2108/257121 https://doi.org/10.1016/j.hemonc.2020.02.005 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A5336F55 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.hemonc.2020.02.005 |
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