Academic Journal
Boron clusters as broadband membrane carriers
| العنوان: | Boron clusters as broadband membrane carriers |
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| المؤلفون: | Barba-Bon, Andrea, Salluce, Giulia, Lostalé-Seijo, Irene, Assaf, Khaleel. I., Hennig, Andreas, Montenegro, Javier, Nau, Werner M. |
| المصدر: | Nature ; volume 603, issue 7902, page 637-642 ; ISSN 0028-0836 1476-4687 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | The membrane translocation of hydrophilic substances constitutes a challenge for their application as therapeutic compounds and labelling probes 1–4 . To remedy this, charged amphiphilic molecules have been classically used as carriers 3,5 . However, such amphiphilic carriers may cause aggregation and non-specific membrane lysis 6,7 . Here we show that globular dodecaborate clusters, and prominently B 12 Br 12 2− , can function as anionic inorganic membrane carriers for a broad range of hydrophilic cargo molecules (with molecular mass of 146–4,500 Da). We show that cationic and neutral peptides, amino acids, neurotransmitters, vitamins, antibiotics and drugs can be carried across liposomal membranes. Mechanistic transport studies reveal that the carrier activity is related to the superchaotropic nature of these cluster anions 8–12 . We demonstrate that B 12 Br 12 2− affects cytosolic uptake of different small bioactive molecules, including the antineoplastic monomethyl auristatin F, the proteolysis targeting chimera dBET1 and the phalloidin toxin, which has been successfully delivered in living cells for cytoskeleton labelling. We anticipate the broad and distinct delivery spectrum of our superchaotropic carriers to be the starting point of conceptually distinct cell-biological, neurobiological, physiological and pharmaceutical studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41586-022-04413-w |
| الاتاحة: | http://dx.doi.org/10.1038/s41586-022-04413-w https://www.nature.com/articles/s41586-022-04413-w.pdf https://www.nature.com/articles/s41586-022-04413-w |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.A52C8A6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41586-022-04413-w |
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