Academic Journal
Endocannabinoid system expression in ovarian epithelial tumors according to the dualistic model of ovarian carcinogenesis
| العنوان: | Endocannabinoid system expression in ovarian epithelial tumors according to the dualistic model of ovarian carcinogenesis |
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| المؤلفون: | Ronchi A., Grauso F., Marino F. Z., Quagliariello V., Maurea N., Facchini G., Montopoli M., Franco R., Berretta M., Messalli E. M. |
| المساهمون: | Ronchi, A., Grauso, F., Marino, F. Z., Quagliariello, V., Maurea, N., Facchini, G., Montopoli, M., Franco, R., Berretta, M., Messalli, E. M. |
| بيانات النشر: | Verduci Editore s.r.l |
| سنة النشر: | 2021 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Cannabinoid receptor, Endocannabinoid system, Epithelial ovarian tumor, Fatty acid amide hydrolase, Kurman's dualistic model |
| الوصف: | OBJECTIVE: Our study aimed to confirm the expression of the endocannabinoid system in the human epithelial ovarian tumors, assessing the immunohistochemical expression of Cannabinoid Receptor Type 1 and Fatty Acid Amide Hydrolase in benign, borderline and malignant tumors. MATERIALS AND METHODS: Cannabinoid Receptor Type 1 and Fatty Acid Amide Hydrolase immunohistochemical expression was determined in 118 epithelial ovarian tumors sequentially treated during the last decade in our department: 36 benign, 34 borderline and 48 malignant neoplasms. Cannabinoid Receptor type 1 and Fatty Acid Amide Hydrolase expression resulted predominantly weak-moderate in the benign and borderline forms. RESULTS: concerning malignant tumors, Cannabinoid Receptor Type 1 expression resulted predominantly moderate-strong in Type I tumors and negative-weak in Type II tumors. Fatty Acid Amide Hydrolase expression resulted, instead, independent by the tumor types. Furthermore, there was no significant difference in the Cannabinoid Receptor Type 1 and Fatty Acid Amide Hydrolase expression relatively to the tumoral stages. CONCLUSIONS: The present study confirmed a variable expression of the endocannabinoid system in human ovarian tumors. Cannabinoid Receptor Type 1 expression was significantly different in malignant epithelial ovarian tumors according to dualistic model of ovarian carcinogenesis. Thus, in the most aggressive types II ovarian tumors, Cannabinoid Receptor Type 1 expression resulted predominantly negative or weak. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34337715; info:eu-repo/semantics/altIdentifier/wos/WOS:000680162900007; volume:25; issue:14; firstpage:4678; lastpage:4686; numberofpages:9; journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES; http://hdl.handle.net/11577/3407095; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85111176072 |
| DOI: | 10.26355/eurrev_202107_26378 |
| الاتاحة: | http://hdl.handle.net/11577/3407095 https://doi.org/10.26355/eurrev_202107_26378 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A4FD8CD6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.26355/eurrev_202107_26378 |
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