Academic Journal
Structure–Activity Relationship of Oleanane-Type Pentacyclic Triterpenoids on Nuclear Factor κB Activation and Intracellular Trafficking and N -Linked Glycosylation of Intercellular Adhesion Molecule-1
| العنوان: | Structure–Activity Relationship of Oleanane-Type Pentacyclic Triterpenoids on Nuclear Factor κB Activation and Intracellular Trafficking and N -Linked Glycosylation of Intercellular Adhesion Molecule-1 |
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| المؤلفون: | Kaori Nakano, Yuka Yokota, Quy Van Vu, Francesca Lagravinese, Takao Kataoka |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 11, p 6026 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | nuclear factor κB, intercellular adhesion molecule-1, N -glycosylation, celastrol, pristimerin, oleanolic acid, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In our previous study, two oleanane-type pentacyclic triterpenoids (oleanolic acid and maslinic acid) were reported to affect the N -glycosylation and intracellular trafficking of intercellular adhesion molecule-1 (ICAM-1). The present study was aimed at investigating the structure–activity relationship of 13 oleanane-type natural triterpenoids with respect to the nuclear factor κB (NF-κB) signaling pathway and the expression, intracellular trafficking, and N -glycosylation of the ICAM-1 protein in human lung adenocarcinoma A549 cells. Hederagenin, echinocystic acid, erythrodiol, and maslinic acid, which all possess two hydroxyl groups, decreased the viability of A549 cells. Celastrol and pristimerin, both of which possess an α , β -unsaturated carbonyl group, decreased cell viability but more strongly inhibited the interleukin-1α-induced NF-κB signaling pathway. Oleanolic acid, moronic acid, and glycyrrhetinic acid interfered with N -glycosylation without affecting the cell surface expression of the ICAM-1 protein. In contrast, α -boswellic acid and maslinic acid interfered with the N -glycosylation of the ICAM-1 protein, which resulted in the accumulation of high-mannose-type N -glycans. Among the oleanane-type triterpenoids tested, α -boswellic acid and maslinic acid uniquely interfered with the intracellular trafficking and N -glycosylation of glycoproteins. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/11/6026; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/085f696e45bb4e2cae007fea142fa2cf |
| DOI: | 10.3390/ijms25116026 |
| الاتاحة: | https://doi.org/10.3390/ijms25116026 https://doaj.org/article/085f696e45bb4e2cae007fea142fa2cf |
| رقم الانضمام: | edsbas.A49DCA7D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25116026 |