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The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

التفاصيل البيبلوغرافية
العنوان: The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection
المؤلفون: Qin, Wanhai, Scicluna, Brendon P., van der Poll, Tom
المصدر: Frontiers in immunology, 12:696280
سنة النشر: 2021
المجموعة: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
مصطلحات موضوعية: Immunology, Transcription, Genetic [MeSH], mechanism, Bacteria/metabolism [MeSH], bacteria, Humans [MeSH], infection, DNA Modification Methylases/metabolism [MeSH], Bacterial Infections/microbiology [MeSH], Gastrointestinal Microbiome [MeSH], Host-Pathogen Interactions [MeSH], Animals [MeSH], Bacterial Infections/genetics [MeSH], Epigenesis, review, immune response, Bacteria/immunology [MeSH], DNA Methylation [MeSH], DNA methylation, Dioxygenases/metabolism [MeSH], Bacterial Infections/immunology [MeSH]
الوصف: Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years. The extent of DNA methylation is well known to regulate gene expression. Whilst historically DNA methylation was considered to be a stable epigenetic modification, accumulating evidence indicates that DNA methylation patterns can be altered rapidly upon exposure of cells to changing environments and pathogens. Furthermore, the action of proteins regulating DNA methylation, particularly DNA methyltransferases and ten-eleven translocation methylcytosine dioxygenases, may be modulated, at least in part, by bacteria. This review discusses the principles of DNA methylation, and recent insights about the regulation of host DNA methylation during bacterial infection.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
Relation: https://repository.publisso.de/resource/frl:6479594; https://doi.org/10.3389/fimmu.2021.696280; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358789/
DOI: 10.3389/fimmu.2021.696280
الاتاحة: https://repository.publisso.de/resource/frl:6479594
https://doi.org/10.3389/fimmu.2021.696280
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358789/
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.A48DCBC0
قاعدة البيانات: BASE
الوصف
DOI:10.3389/fimmu.2021.696280