Academic Journal
RATIONALE 301 study: tislelizumab versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma
| العنوان: | RATIONALE 301 study: tislelizumab versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma |
|---|---|
| المؤلفون: | Qin, S, Finn, RS, Kudo, M, Meyer, T, Vogel, A, Ducreux, M, Macarulla, TM, Tomasello, G, Boisserie, F, Hou, J, Li, X, Song, J, Zhu, AX |
| المصدر: | Future Oncology , 15 (16) pp. 1811-1822. (2019) |
| سنة النشر: | 2019 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | HCC, PD-1, hepatocellular carcinoma, tislelizumab |
| الوصف: | Advanced, unresectable hepatocellular carcinoma (HCC) has a poor prognosis with median life expectancy of approximately 1 year. Overexpression of PD-L1 in tumor cells and PD-1 on tumor-infiltrating T cells has been associated with poorer prognosis, more advanced disease and higher recurrence rates in HCC. Monoclonal antibodies against PD-1 have demonstrated antitumor activity in patients with solid tumors, including HCC. Tislelizumab, an investigational, humanized IgG4 monoclonal antibody with high affinity and binding specificity for PD-1, has demonstrated preliminary antitumor activity in HCC. Here we describe a head-to-head Phase III study comparing the efficacy, safety and tolerability of tislelizumab with sorafenib as first-line treatment in unresectable HCC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10077677/1/Meyer_RATIONALE%20301%20stud.%20Tislelizumab%20versus%20sorafenib%20as%20first-line%20treatment%20for%20unresectable%20hepatocellular%20carcinoma_VoR.pdf; https://discovery.ucl.ac.uk/id/eprint/10077677/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10077677/1/Meyer_RATIONALE%20301%20stud.%20Tislelizumab%20versus%20sorafenib%20as%20first-line%20treatment%20for%20unresectable%20hepatocellular%20carcinoma_VoR.pdf https://discovery.ucl.ac.uk/id/eprint/10077677/ |
| Rights: | open |
| رقم الانضمام: | edsbas.A4822CD4 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |