Academic Journal
Modelling flock heterogeneity in the transmission of peste des petits ruminants virus and its impact on the effectiveness of vaccination for eradication
| العنوان: | Modelling flock heterogeneity in the transmission of peste des petits ruminants virus and its impact on the effectiveness of vaccination for eradication |
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| المؤلفون: | Savagar, Bethan, Jones, Bryony, A, Arnold, Mark, Walker, Martin, Fournié, Guillaume |
| المساهمون: | Royal Veterinary College London, University of London London, National Reference Centre for the Scientific Research in Infectious Diseases at the Animal/Human interface – WOAH Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Animal and Plant Health Agency Addlestone, UK (APHA), Parasites and Vectors Division, London Centre for Neglected Tropical Disease Research, Natural History Museum, Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques (UMR EPIA), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | ISSN: 1755-4365. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Université de Lyon: HAL |
| مصطلحات موضوعية: | Peste des petits ruminants, Heterogeneous transmission, Mathematical modeling, PPR, Vaccination, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health |
| الوصف: | Online ahead of print ; International audience ; Peste des petits ruminants (PPR) is an acute infectious disease of small ruminants targeted for global eradication by 2030. The Global Strategy for Control and Eradication (GSCE) recommends mass vaccination targeting 70% coverage of small ruminant populations in PPR-endemic regions. These small ruminant populations are diverse with heterogeneous mixing patterns that may influence PPR virus (PPRV) transmission dynamics. This paper evaluates the impact of heterogeneous mixing on (i) PPRV transmission and (ii) the likelihood of different vaccination strategies achieving PPRV elimination, including the GSCE recommended strategy. We develop models simulating heterogeneous transmission between hosts, including a metapopulation model of PPRV transmission between villages in lowland Ethiopia fitted to serological data. Our results demonstrate that although heterogeneous mixing of small ruminant populations increases the instability of PPRV transmission-increasing the chance of fadeout in the absence of intervention-a vaccination coverage of 70% may be insufficient to achieve elimination if high-risk populations are not targeted. Transmission may persist despite very high vaccination coverage (>90% small ruminants) if vaccination is biased towards more accessible but lower-risk populations such as sedentary small ruminant flocks. These results highlight the importance of characterizing small ruminant mobility patterns and identifying high-risk populations for vaccination and support a move towards targeted, risk-based vaccination programmes in the next phase of the PPRV eradication programme. Our modelling approach also illustrates a general framework for incorporating heterogeneous mixing patterns into models of directly transmitted infectious diseases where detailed contact data are limited. This study improves understanding of PPRV transmission and elimination in heterogeneous small ruminant populations and should be used to inform and optimize the design of PPRV ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37935076; hal-04281521; https://hal.inrae.fr/hal-04281521; https://hal.inrae.fr/hal-04281521/document; https://hal.inrae.fr/hal-04281521/file/FournieG_Epidemics.pdf; PUBMED: 37935076 |
| DOI: | 10.1016/j.epidem.2023.100725 |
| الاتاحة: | https://hal.inrae.fr/hal-04281521 https://hal.inrae.fr/hal-04281521/document https://hal.inrae.fr/hal-04281521/file/FournieG_Epidemics.pdf https://doi.org/10.1016/j.epidem.2023.100725 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A46526DB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.epidem.2023.100725 |
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