التفاصيل البيبلوغرافية
| العنوان: |
Formulation and In Vitro Evaluation of Moxifloxacin Hydrochloride-Loaded Polymeric Nanoparticles for Ocular Application |
| المؤلفون: |
Yurtdaş Kırımlıoğlu, Gülsel, Özer, Sinan, Büyükköroğlu, Gülay, Yazan, Yasemin |
| المساهمون: |
Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Büyükköroğlu, Gülay, Yazan, Yasemin |
| بيانات النشر: |
Colegio Farmaceuticos Provincia De Buenos Aires |
| سنة النشر: |
2018 |
| المجموعة: |
Anadolu University Institutional Repository |
| مصطلحات موضوعية: |
Eudragit (R) Rs 100, Moxifloxacin Hydrochloride, Ocular Delivery, Polymeric Nanoparticle, Spray-Drying |
| الوصف: |
WOS: 000446302000021 ; The primary purpose of this study was to extend the time of interaction of the carrier with the negatively charged ocular surface for enhanced penetration in order to improve ocular bioavailability. Moxifloxacin hydrochloride (MOX) was successfully incorporated into cationic Eudragit (R) RS 100 nanoparticles (NPs) by spray-drying process. Particle size and zeta potential measurements, entrapment efficiency, morphological, thermal, FTIR and NMR analyses and MOX quantification by high performance liquid chromatography (HPLC) method were performed for characterizing the formulations prepared. In vitro release profiles indicated prolonged release of MOX from NPs which followed Korsmeyer-Peppas kinetic model. Cytotoxicity results showed that pure MOX and MOX-loaded NPs were not toxic at all concentrations for 24 h. Moreover, NPs remained stable for 3 months of storage under accelerated conditions. Conclusively, depending on the in vitro results obtained in this study, Eudragit (R) RS 100 NPs seem to be promising for enhancement of ocular bioavailability of MOX. ; Anadolu University Scientific Research Project Foundation [1603S112] ; The authors would like to thank to Exp.Chem. Serkan Levent for his assistance in FTIR and NMR analyses and Assoc. Prof.Dr. Ozer Gok for his help in taking SEM images. This study was financed by Anadolu University Scientific Research Project Foundation (No: 1603S112). |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0326-2383 |
| Relation: |
Latin American Journal of Pharmacy; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11421/13865; 37; 1850; 1862 |
| الاتاحة: |
https://hdl.handle.net/11421/13865 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| رقم الانضمام: |
edsbas.A460079 |
| قاعدة البيانات: |
BASE |