Academic Journal
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.
| العنوان: | Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. |
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| المؤلفون: | Mauvoisin, D., Atger, F., Dayon, L., Núñez Galindo, A., Wang, J., Martin, E., Da Silva, L., Montoliu, I., Collino, S., Martin, F.P., Ratajczak, J., Cantó, C., Kussmann, M., Naef, F., Gachon, F. |
| المصدر: | Cell reports, vol. 20, no. 7, pp. 1729-1743 |
| سنة النشر: | 2017 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | ARNTL Transcription Factors/deficiency, ARNTL Transcription Factors/genetics, Acetylation, Animals, Circadian Clocks/physiology, Circadian Rhythm/physiology, Cryptochromes/deficiency, Cryptochromes/genetics, Eating/physiology, Liver/enzymology, Lysine, Metabolic Networks and Pathways/physiology, Mice, Inbred C57BL, Knockout, Mitochondrial Proteins/genetics, Mitochondrial Proteins/metabolism, NAD/metabolism, Photoperiod, Protein Processing, Post-Translational, Proteome/genetics, Proteome/metabolism, Sirtuin 3/genetics, Sirtuin 3/metabolism, NAD(+), SILAC proteomics, SIRT3, circadian clock, liver metabolism |
| الوصف: | Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is therefore highly relevant in the context of circadian biology, but its characterization on the proteome-wide scale and its circadian clock dependence are still poorly described. Here, we provide a comprehensive and rhythmic acetylome map of the mouse liver. Rhythmic acetylated proteins showed subcellular localization-specific phases that correlated with the related metabolites in the regulated pathways. Mitochondrial proteins were over-represented among the rhythmically acetylated proteins and were highly correlated with SIRT3-dependent deacetylation. SIRT3 activity being nicotinamide adenine dinucleotide (NAD) + level-dependent, we show that NAD + is orchestrated by both feeding rhythms and the circadian clock through the NAD + salvage pathway but also via the nicotinamide riboside pathway. Hence, the diurnal acetylome relies on a functional circadian clock and affects important diurnal metabolic pathways in the mouse liver. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/28813682; info:eu-repo/semantics/altIdentifier/eissn/2211-1247; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E24884033C826; https://serval.unil.ch/notice/serval:BIB_E24884033C82; https://serval.unil.ch/resource/serval:BIB_E24884033C82.P003/REF.pdf |
| DOI: | 10.1016/j.celrep.2017.07.065 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_E24884033C82 https://doi.org/10.1016/j.celrep.2017.07.065 https://serval.unil.ch/resource/serval:BIB_E24884033C82.P003/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E24884033C826 |
| Rights: | info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimer |
| رقم الانضمام: | edsbas.A432758 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2017.07.065 |
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