Academic Journal
Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase
| العنوان: | Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase |
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| المؤلفون: | Fanelli, Matthew J, Welsh, Christofer, Lui, Dominique S, Smulan, Lorissa J, Walker, Amy K |
| المساهمون: | Medicine, Morningside Graduate School of Biomedical Sciences, Program in Molecular Medicine, Matthew J Fanelli, Christofer M Welsh |
| المصدر: | Science advances ; 9 ; 49 ; eadi5545 ; United States |
| سنة النشر: | 2024 |
| المجموعة: | University of Massachusetts, Medical School: eScholarship@UMMS |
| الوصف: | Infection response and other immunity-linked genes (ILGs) were first named in Caenorhabditis elegans-based expression after pathogen challenge, but many are also up-regulated when lipid metabolism is perturbed. Why pathogen attack and metabolic changes both increase ILGs is unclear. We find that ILGs are activated when phosphatidylcholine (PC) levels change in membranes of secretory organelles in C. elegans. RNAi targeting of the ADP-ribosylation factor arf-1, which disrupts the Golgi and secretory function, also activates ILGs. Low PC limits ARF-1 function, suggesting a mechanism for ILG activation via lipid metabolism, as part of a membrane stress response acting outside the ER. RNAi of selected ILGs uncovered defects in the secretion of two GFP reporters and the accumulation of a pathogen-responsive complement C1r/C1s, Uegf, Bmp1 (CUB) domain fusion protein. Our data argue that up-regulation of some ILGs is a coordinated response to changes in trafficking and may act to counteract stress on secretory function. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2375-2548 |
| Relation: | Science Advances; https://doi.org/10.1126/sciadv.adi5545; Fanelli MJ, Welsh CM, Lui DS, Smulan LJ, Walker AK. Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase. Sci Adv. 2023 Dec 8;9(49):eadi5545. doi:10.1126/sciadv.adi5545. Epub 2023 Dec 6. PMID: 38055815; PMCID: PMC10699786.; http://hdl.handle.net/20.500.14038/53106 |
| DOI: | 10.1126/sciadv.adi5545 |
| الاتاحة: | https://doi.org/10.1126/sciadv.adi5545 https://hdl.handle.net/20.500.14038/53106 |
| Rights: | Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). ; Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.A43129E3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23752548 |
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| DOI: | 10.1126/sciadv.adi5545 |