Conference
Identification of deregulated transcription factors involved in subtypes of cancers
| العنوان: | Identification of deregulated transcription factors involved in subtypes of cancers |
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| المؤلفون: | Champion, Magali, Chiquet, Julien, Neuvial, Pierre, Elati, Mohamed, Radvanyi, François, Birmelé, Etienne, E. |
| المساهمون: | Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions - CNRS Mathématiques (INSMI-CNRS)-Centre National de la Recherche Scientifique (CNRS), Mathématiques et Informatique Appliquées (MIA Paris-Saclay), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques et Modélisation d'Evry (LaMME), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de biologie systémique et synthétique (ISSB), Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Université Paris Sciences et Lettres (PSL) |
| المصدر: | Proceedings of the 12th International Conference on Bioinformatics and Computational Biology ; https://hal.science/hal-01516892 ; Proceedings of the 12th International Conference on Bioinformatics and Computational Biology, Mar 2020, SAN FRANCISCO, United States. pp.1--10, ⟨10.29007/v7qj⟩ |
| بيانات النشر: | CCSD |
| سنة النشر: | 2020 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Cancer systems biology, Gene regulatory networks, Deregulation, [STAT.AP]Statistics [stat]/Applications [stat.AP] |
| جغرافية الموضوع: | SAN FRANCISCO, United States |
| الوصف: | International audience ; We propose a methodology for the identification of transcription factors involved in the deregulation of genes in tumoral cells. This strategy is based on the inference of a reference gene regulatory network that connects transcription factors to their downstream targets using gene expression data. The behavior of genes in tumor samples is then carefully compared to this network of reference to detect deregulated target genes. A linear model is finally used to measure the ability of each transcription factor to explain those deregulations. We assess the performance of our method by numerical experiments on a breast cancer data set. We show that the information about deregulation is complementary to the expression data as the combination of the two improves the supervised classification performance of samples into cancer subtypes. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/arxiv/2004.08312; ARXIV: 2004.08312 |
| DOI: | 10.29007/v7qj |
| الاتاحة: | https://hal.science/hal-01516892 https://hal.science/hal-01516892v2/document https://hal.science/hal-01516892v2/file/LIONS_HAL.pdf https://doi.org/10.29007/v7qj |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A413904 |
| قاعدة البيانات: | BASE |
| DOI: | 10.29007/v7qj |
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