Academic Journal
Treatment of walking impairment in multiple sclerosis with dalfampridine
| العنوان: | Treatment of walking impairment in multiple sclerosis with dalfampridine |
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| المؤلفون: | Blight, Andrew R. |
| المصدر: | Therapeutic Advances in Neurological Disorders ; volume 4, issue 2, page 99-109 ; ISSN 1756-2864 1756-2864 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2011 |
| الوصف: | Potassium channel blockade has long been considered a potential therapeutic strategy for treatment of multiple sclerosis (MS) based on the pathophysiology of demyelinated axons. Dalfampridine, which is also known as fampridine or 4-aminopyridine (4-AP), is the potassium channel blocker that has been studied most extensively in MS and other demyelinating neurologic disorders. An extended-release formulation of dalfampridine was recently approved by the US Food and Drug Administration to improve walking in patients with MS. In randomized, double-blind, placebo-controlled trials, with dalfampridine extended release tablets 10 mg taken twice daily, about 12 h apart, walking speed was improved in approximately one-third of treated patients; in these patients, average walking speed on therapy was about 25% above baseline. This improvement was clinically meaningful as assessed by concurrent measurement of patient-reported severity of walking-related disability. Dalfampridine extended release tablets were generally well tolerated, with a range of adverse effects that appear to be related to increases in central nervous system excitation. There is a dose-dependent increase in the occurrence of seizures at doses higher than the recommended 10 mg twice daily. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1756285611403960 |
| الاتاحة: | http://dx.doi.org/10.1177/1756285611403960 http://journals.sagepub.com/doi/pdf/10.1177/1756285611403960 |
| Rights: | http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.A40618A6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1756285611403960 |
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