Academic Journal
Bentonite- and Palygorskite-Based Gels for Topical Drug Delivery Applications
| العنوان: | Bentonite- and Palygorskite-Based Gels for Topical Drug Delivery Applications |
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| المؤلفون: | Ruggeri, Marco, Sánchez-Espejo, Rita, Casula, Luca, Sandri, Giuseppina, Perioli, Luana, Cardia, Maria Cristina, Lai, Francesco, Viseras, César |
| المساهمون: | Ruggeri, Marco, Sánchez-Espejo, Rita, Casula, Luca, Sandri, Giuseppina, Perioli, Luana, Cardia, Maria Cristina, Lai, Francesco, Viseras, César |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Cagliari: UNICA IRIS |
| مصطلحات موضوعية: | clay, dermal delivery, diclofenac acid, nanocrystals |
| الوصف: | Bentonite or palygorskite-based hydrogels have recently been suggested as a strategy to increase bioavailability and control the retention and release of therapeutic candidates. In this work, clay-based hydrogels loaded with diclofenac acid nanocrystals have been successfully designed and developed. The aim was to improve diclofenac solubility, its dissolution rate and to enhance its local bioavailability after topical application. For this purpose, diclofenac acid nanocrystals were prepared by wet media milling technology and then loaded into inorganic hydrogels based on bentonite and/or palygorskite. Diclofenac acid nanocrystals were characterized by morphology, size, and zeta potential. Moreover, rheological behavior, morphology, solid state, release studies, and in vitro skin penetration/permeation of diclofenac acid nanocrystals-loaded hydrogels were performed. The hydrogels were characterized by a crystalline structure, and demonstrated that the inclusion of diclofenac in clay-based hydrogels resulted in an increased thermal stability. The presence of both palygorskite and bentonite reduced nanocrystal mobility, and consequently its release and penetration into the skin. On the other hand, bentonite- or palygorskite-based hydrogels revealed great potential as an alternative strategy to enhance topical bioavailability of DCF nanocrystals, enhancing their penetration to the deeper skin layers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37111738; info:eu-repo/semantics/altIdentifier/wos/WOS:000979267800001; volume:15; issue:4; firstpage:1; lastpage:13; numberofpages:13; journal:PHARMACEUTICS; https://hdl.handle.net/11584/366125; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85157981170 |
| DOI: | 10.3390/pharmaceutics15041253 |
| الاتاحة: | https://hdl.handle.net/11584/366125 https://doi.org/10.3390/pharmaceutics15041253 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A3EADB4E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pharmaceutics15041253 |
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