التفاصيل البيبلوغرافية
| العنوان: |
Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL) |
| المؤلفون: |
Paula Abal, M. Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes Vieytes, Luis Botana |
| المصدر: |
Toxins; Volume 9; Issue 3; Pages: 75 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2017 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
acute oral toxicity, European molluscs, lethal dose 50 (LD 50 ), No Observed Adverse Effect Level (NOAEL), risk assessment, tetrodotoxin |
| جغرافية الموضوع: |
agris |
| الوصف: |
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity data are required. In this study, a 4-level Up and Down Procedure was designed in order to determine for the first time the oral lethal dose 50 (LD50) and the No Observed Adverse Effect Level (NOAEL) in mice by using an accurate well-characterized TTX standard. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Marine and Freshwater Toxins; https://dx.doi.org/10.3390/toxins9030075 |
| DOI: |
10.3390/toxins9030075 |
| الاتاحة: |
https://doi.org/10.3390/toxins9030075 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.A3CBBF00 |
| قاعدة البيانات: |
BASE |