التفاصيل البيبلوغرافية
| العنوان: |
THERAPUTIC PROFILE OF MANIDIPINE AND LERCANIDIPINE IN HYPERTENSIVE PATIENTS |
| المؤلفون: |
E. Casiglia, A. Mazza, V. Tikhonoff, G. Basso, B. Martini, R. Scarpa, A. C. Pessina |
| المساهمون: |
Casiglia, E., Mazza, A., Tikhonoff, V., Basso, G., Martini, B., Scarpa, R., Pessina, A. C. |
| سنة النشر: |
2004 |
| المجموعة: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| الوصف: |
Manidipine is a third-generation dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. In clinical studies, manidipine has been shown to significantly lower office and 24-h blood pressure compared with placebo in patients with essential hypertension. The resulting reduction in blood pressure is maintained over 24 h, with preservation of the circadian blood pressure pattern; its blood pressure-lowering capacity appears to be similar to that of other calcium antagonists. In elderly patients with mild-to-moderate essential hypertension, manidipine is able to significantly decrease blood pressure compared with placebo for up to 3 years of treatment. The drug also significantly lowers blood pressure in patients with hypertension and concomitant Type 2 diabetes mellitus or renal impairment, and is devoid of adverse metabolic effects. It is well-tolerated with few untoward adverse effects related to vasodilation. In particular, manidipine appears to have less potential for pedal edema than other calcium channel blockers. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| Relation: |
volume:27; firstpage:357; lastpage:369; numberofpages:12; journal:ADVANCES IN THERAPY; http://hdl.handle.net/11577/1340929 |
| الاتاحة: |
http://hdl.handle.net/11577/1340929 |
| رقم الانضمام: |
edsbas.A3A39D51 |
| قاعدة البيانات: |
BASE |