Academic Journal
Whole brain myelin mapping using T1- and T2-weighted MR imaging data
| العنوان: | Whole brain myelin mapping using T1- and T2-weighted MR imaging data |
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| المؤلفون: | Ganzetti, Marco, Wenderoth, Nicole, Mantini, Dante |
| المصدر: | Frontiers in Human Neuroscience, 8 |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2014 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | Brain mapping, Magnetic resonance imaging, Myelin enhanced contrast, Brain integrity assessment, Myelin mapping |
| الوصف: | Despite recent advancements in MR imaging, non-invasive mapping of myelin in the brain still remains an open issue. Here we attempted to provide a potential solution. Specifically, we developed a processing workflow based on T1-w and T2-w MR data to generate an optimized myelin enhanced contrast image. The workflow allows whole brain mapping using the T1-w/T2-w technique, which was originally introduced as a non-invasive method for assessing cortical myelin content. The hallmark of our approach is a retrospective calibration algorithm, applied to bias-corrected T1-w and T2-w images, that relies on image intensities outside the brain. This permits standardizing the intensity histogram of the ratio image, thereby allowing for across-subject statistical analyses. Quantitative comparisons of image histograms within and across different datasets confirmed the effectiveness of our normalization procedure. Not only did the calibrated T1-w/T2-w images exhibit a comparable intensity range, but also the shape of the intensity histograms was largely corresponding. We also assessed the reliability and specificity of the ratio image compared to other MR-based techniques, such as magnetization transfer ratio (MTR), fractional anisotropy (FA), and fluid-attenuated inversion recovery (FLAIR). With respect to these other techniques, T1-w/T2-w had consistently high values, as well as low inter-subject variability, in brain structures where myelin is most abundant. Overall, our results suggested that the T1-w/T2-w technique may be a valid tool supporting the non-invasive mapping of myelin in the brain. Therefore, it might find important applications in the study of brain development, aging and disease. ; ISSN:1662-5161 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/000341291000001; http://hdl.handle.net/20.500.11850/88741 |
| DOI: | 10.3929/ethz-b-000088741 |
| الاتاحة: | https://hdl.handle.net/20.500.11850/88741 https://doi.org/10.3929/ethz-b-000088741 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/3.0/ ; Creative Commons Attribution 3.0 Unported |
| رقم الانضمام: | edsbas.A39F30EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000088741 |
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