Academic Journal
Fenbendazole Controls In Vitro Growth, Virulence Potential, and Animal Infection in the Cryptococcus Model
| العنوان: | Fenbendazole Controls In Vitro Growth, Virulence Potential, and Animal Infection in the Cryptococcus Model |
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| المؤلفون: | de Oliveira, Haroldo C., Joffe, Luna S., Simon, Karina S., Castelli, Rafael F., Reis, Flavia C. G., Bryan, Arielle M., Borges, Beatriz S., Medeiros, Lia C. Soares, Bocca, Anamelia L., Del Poeta, Maurizio, Rodrigues, Marcio L. |
| المساهمون: | HHS | National Institutes of Health, U.S. Department of Veterans Affairs, MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Fundação Oswaldo Cruz, Ministério da Saúde |
| المصدر: | Antimicrobial Agents and Chemotherapy ; volume 64, issue 6 ; ISSN 0066-4804 1098-6596 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2020 |
| الوصف: | The human diseases caused by the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii are associated with high indices of mortality and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anticryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/aac.00286-20 |
| DOI: | 10.1128/AAC.00286-20 |
| الاتاحة: | http://dx.doi.org/10.1128/aac.00286-20 https://journals.asm.org/doi/pdf/10.1128/AAC.00286-20 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.A35CF0F4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/aac.00286-20 |
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