Academic Journal
Myocardial energy response to glyceryl trinitrate: physiology revisited
| العنوان: | Myocardial energy response to glyceryl trinitrate: physiology revisited |
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| المؤلفون: | Watson, WD, Green, PG, Valkovič, L, Herring, N, Neubauer, S, Rider, OJ |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2022 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Objective: Although intravenous nitrates are commonly used in clinical medicine, they have been shown to increase myocardial oxygen consumption and inhibit complex IV of the electron transport chain. As such we sought to measure whether myocardial energetics were impaired during glyceryl trinitrate (GTN) infusion. Methods: 10 healthy volunteers underwent cardiac magnetic resonance imaging to assess cardiac function and 31phosphorus magnetic resonance spectroscopy to measure Phosphocreatine/ATP (PCr/ATP) ratio and creatine kinase forward rate constant (CK kf) before and during an intravenous infusion of GTN. Results: During GTN infusion, mean arterial pressure (78 ± 7 vs. 65 ± 6 mmHg, p Conclusion: During GTN infusion, despite reduced LV stroke work and maintained cardiac output, there was a 44% increase in myocardial ATP delivery through CK. As PCr/ATP fell, this increase in ATP demand coincided with GTN-induced impairment of mitochondrial oxidative phosphorylation. Overall, this suggests that while GTN reduces cardiac work, it does so at the expense of increasing ATP demand beyond the capacity to increase ATP production. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://ora.ox.ac.uk/objects/uuid:0914f432-bd7e-4442-a488-0cb1487a094d; https://doi.org/10.3389/fphys.2021.790525 |
| DOI: | 10.3389/fphys.2021.790525 |
| الاتاحة: | https://doi.org/10.3389/fphys.2021.790525 https://ora.ox.ac.uk/objects/uuid:0914f432-bd7e-4442-a488-0cb1487a094d |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.A316D91 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fphys.2021.790525 |
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