Academic Journal
Corneal confocal microscopy to detect early immune-mediated small nerve fibre loss in AL amyloidosis
| العنوان: | Corneal confocal microscopy to detect early immune-mediated small nerve fibre loss in AL amyloidosis |
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| المؤلفون: | Thimm, Andreas, Carpinteiro, Alexander, Oubari, Sara, Papathanasiou, Maria, Kessler, Lukas, Rischpler, Christoph, Malik, Rayaz Ahmed, Reinhardt, Hans Christian, Rassaf, Tienush, Herrmann, Ken, Kleinschnitz, Christoph, Stettner, Mark, Hagenacker, Tim |
| سنة النشر: | 2022 |
| المجموعة: | University of Duisburg-Essen: DuEPublico (Duisburg Essen Publications online) |
| مصطلحات موضوعية: | ScholarlyArticle, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurologie, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Hämatologie und Stammzelltransplantation, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Kardiologie und Angiologie, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Nuklearmedizin |
| الوصف: | Objective: Light chain (AL) amyloidosis is a life-threatening disorder characterised by extracellular deposition of amyloid leading to dysfunction of multiple organs. Peripheral nerve involvement, particularly small fibre neuropathy, may be associated with poorer survival. Corneal confocal microscopy (CCM) is a rapid and non-invasive imaging technique to quantify corneal small nerve fibres and immune cells in vivo. We aimed to evaluate CCM as a tool for early diagnosis of peripheral nerve involvement in AL amyloidosis. Methods: CCM and nerve conduction studies (NCS) were undertaken in 21 newly diagnosed, treatment-naïve AL amyloidosis patients and 21 age- and sex-matched healthy controls. Corneal nerve fibre density (CNFD), corneal nerve branch density and fibre length, and cell infiltrates were quantified in the sub-basal layer of the cornea. Results: There was a significant reduction in CNFD and nerve fibre length, even without large fibre affection and an increase in cell density, particularly around corneal nerve fibres in patients with AL amyloidosis compared to controls. Additionally, cell infiltration correlated with reduced nerve fibre density in patients with AL amyloidosis, but reduced CNFD did not correlate with laboratory parameters of organ dysfunction. Interpretation: Our study is the first to show that CCM allows rapid non-invasive identification of early small nerve fibre damage associated with immune cell infiltration in patients with AL amyloidosis. CCM detects peripheral nerve involvement more sensitively than NCS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1002/acn3.51565; https://nbn-resolving.org/urn:nbn:de:hbz:465-20231120-164217-6; https://duepublico2.uni-due.de/receive/duepublico_mods_00078905; https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00080812/AnnClinTranslNeurol_2022_9_853-863.pdf |
| DOI: | 10.1002/acn3.51565 |
| الاتاحة: | https://doi.org/10.1002/acn3.51565 https://nbn-resolving.org/urn:nbn:de:hbz:465-20231120-164217-6 https://duepublico2.uni-due.de/receive/duepublico_mods_00078905 https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00080812/AnnClinTranslNeurol_2022_9_853-863.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A303136B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/acn3.51565 |
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