Academic Journal
A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition
| العنوان: | A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition |
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| المؤلفون: | Picariello, Federica, Hulme, Katrin, Seaton, Natasha, Hudson, Joanna, Norton, Sam, Wroe, Abby, Moss-Morris, Rona |
| المصدر: | Picariello , F , Hulme , K , Seaton , N , Hudson , J , Norton , S , Wroe , A & Moss-Morris , R 2024 , ' A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition ' , Psychological medicine , vol. 54 , no. 8 , pp. 1796-1809 . https://doi.org/10.1017/S0033291723003756 |
| سنة النشر: | 2024 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Anxiety, chronic medical condition, cognitive behaviour therapy, depression, Digital therapy, illness-related distress, inflammatory bowel disease, kidney disease, multiple sclerosis, psoriasis, transdiagnostic, CBT |
| الوصف: | Background To evaluate the clinical efficacy of COMPASS, a therapist-supported digital therapeutic for reducing psychological distress (anxiety/depression) in people living with long-term physical health conditions (LTCs). Methods A two-armed randomized-controlled trial recruiting from LTC charities. Participants with anxiety and/or depression symptoms related to their LTC(s) were randomized (concealed allocation via independent administrator) to COMPASS (access to 11 tailored modules plus five thirty-minute therapist support sessions) or standard charity support (SCS). Assessments were completed online pre-randomization, at 6- and 12-weeks post-randomization. Primary outcome was Patient Health Questionnaire Anxiety and Depression Scale; PHQ-ADS measured at 12-weeks. Analysis used intention-to-treat principles with adjusted mean differences estimated using linear mixed-effects models. Data-analyst was blinded to group allocation. Results 194 participants were randomized to COMPASS (N = 94) or SCS (N = 100). At 12-weeks, mean level of psychological distress was 6.82 (95% confidence interval; CI 4.55-9.10) points lower (p < 0.001) in the COMPASS arm compared with SCS (standardized mean difference of 0.71 (95% CI 0.48-0.95)). The COMPASS arm also showed moderate significant treatment effects on secondary outcomes including depression, anxiety and illness-related distress and small significant effects on functioning and quality-of-life. Rates of adverse events were comparable across the arms. Deterioration in distress at 12-weeks was observed in 2.2% of the SCS arm, and no participants in the COMPASS arm. Conclusion Compared with SCS, COMPASS digital therapeutic with minimal therapist input reduces psychological distress at post-treatment (12-weeks). COMPASS offers a potentially scalable implementation model for health services but its translation to these contexts needs further evaluating. Trial Registration NCT04535778. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://kclpure.kcl.ac.uk/portal/en/publications/9fe79196-5ef2-46ce-9416-105918cc2cb4 |
| DOI: | 10.1017/S0033291723003756 |
| الاتاحة: | https://kclpure.kcl.ac.uk/portal/en/publications/9fe79196-5ef2-46ce-9416-105918cc2cb4 https://doi.org/10.1017/S0033291723003756 http://www.scopus.com/inward/record.url?scp=85187252886&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A2CFF0A5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/S0033291723003756 |
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