Academic Journal
Targeting ferroptosis as a vulnerability in pulmonary diseases
| العنوان: | Targeting ferroptosis as a vulnerability in pulmonary diseases |
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| المؤلفون: | Li Yang, Li-mian Cao, Xiao-ju Zhang, Bo Chu |
| المصدر: | Cell Death and Disease, Vol 13, Iss 7, Pp 1-14 (2022) |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) are highly susceptible to lipid peroxidation under oxidative stress. Numerous pulmonary diseases occurrences and degenerative pathologies are driven by ferroptosis. This review discusses the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection. Additionally, it is proposed that targeting ferroptosis is a potential treatment for pulmonary diseases, particularly drug-resistant lung cancer or antibiotic-resistant pulmonary infection, and reduces treatment-related adverse events. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-4889 |
| Relation: | https://doi.org/10.1038/s41419-022-05070-7; https://doaj.org/toc/2041-4889; https://doaj.org/article/cd55fed55dc8405fa6a2ed7a9b320b1a |
| DOI: | 10.1038/s41419-022-05070-7 |
| الاتاحة: | https://doi.org/10.1038/s41419-022-05070-7 https://doaj.org/article/cd55fed55dc8405fa6a2ed7a9b320b1a |
| رقم الانضمام: | edsbas.A2CA4BE2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20414889 |
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| DOI: | 10.1038/s41419-022-05070-7 |