Academic Journal
Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy
| العنوان: | Staging of colorectal liver metastases after preoperative chemotherapy. Diffusion-weighted imaging in combination with Gd-EOB-DTPA MRI sequences increases sensitivity and diagnostic accuracy |
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| المؤلفون: | MACERA, ANNALISA, PETRACCHINI, MASSIMO, REGGE, Daniele, Lario, Chiara, Gallo, Teresa, Floriani, Irene, Ribero, Dario, Capussotti, Lorenzo, Cirillo, Stefano |
| المساهمون: | Macera, Annalisa, Lario, Chiara, Petracchini, Massimo, Gallo, Teresa, Regge, Daniele, Floriani, Irene, Ribero, Dario, Capussotti, Lorenzo, Cirillo, Stefano |
| سنة النشر: | 2013 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | Chemotreated patient, Colorectal liver metastase, DWI, Gd-EOB-DTPA enhanced MRI, Small lesion, Aged, Antineoplastic Agent, Carcinoma, Colorectal Neoplasm, Contrast Media, Drug Therapy, Female, Human, Liver Neoplasm, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Staging, Preoperative Care, Reproducibility of Result, Sensitivity and Specificity, Gadolinium DTPA, Radiology, Nuclear Medicine and Imaging |
| الوصف: | OBJECTIVES: To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. METHODS: Thirty-two consecutive patients with a total of 166 liver lesions were retrospectively enrolled. Of the lesions, 144 (86.8 %) were metastatic at pathology. Three image sets (1, Gd-EOB-DTPA; 2, DWI; 3, combined Gd-EOB-DTPA and DWI) were independently reviewed by two observers. Statistical analysis was performed on a per-lesion basis. RESULTS: Evaluation of image set 1 correctly identified 127/166 lesions (accuracy 76.5 %; 95 % CI 69.3-82.7) and 106/144 metastases (sensitivity 73.6 %, 95 % CI 65.6-80.6). Evaluation of image set 2 correctly identified 108/166 (accuracy 65.1 %, 95 % CI 57.3-72.3) and 87/144 metastases (sensitivity of 60.4 %, 95 % CI 51.9-68.5). Evaluation of image set 3 correctly identified 148/166 (accuracy 89.2 %, 95 % CI 83.4-93.4) and 131/144 metastases (sensitivity 91 %, 95 % CI 85.1-95.1). Differences were statistically significant (P < 0.001). Notably, similar results were obtained analysing only small lesions (<1 cm). CONCLUSIONS: The combination of DWI with Gd-EOB-DTPA-enhanced MRI imaging significantly increases the diagnostic accuracy and sensitivity in patients with colorectal liver metastases treated with preoperative chemotherapy, and it is particularly effective in the detection of small lesions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/22976920; info:eu-repo/semantics/altIdentifier/wos/WOS:000314532500018; volume:23; issue:3; firstpage:739; lastpage:747; numberofpages:9; journal:EUROPEAN RADIOLOGY; http://hdl.handle.net/2318/1548797; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84878620744 |
| DOI: | 10.1007/s00330-012-2658-0 |
| الاتاحة: | http://hdl.handle.net/2318/1548797 https://doi.org/10.1007/s00330-012-2658-0 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A2B65B61 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00330-012-2658-0 |
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