Academic Journal
Apoptosis-inducing factor regulates death in peripheral T cells
| العنوان: | Apoptosis-inducing factor regulates death in peripheral T cells |
|---|---|
| المؤلفون: | Srivastava, Smita, Banerjee, Hridesh, Chaudhry, Ashutosh, Khare, Anupriya, Sarin, Apurva, George, Anna, Bal, Vineeta, Durdik, Jeannine M., Rath, Satyajit |
| بيانات النشر: | American Association of Immunologists |
| سنة النشر: | 2007 |
| المجموعة: | Indian Academy of Sciences: Publication of Fellows |
| مصطلحات موضوعية: | QH301 Biology |
| الوصف: | Apoptosis-inducing factor (Aif) is a mitochondrial flavoprotein with multiple roles in apoptosis as well as in cellular respiration and redox regulation. The harlequin (Hq) mouse strain carries an aif locus modification causing reduced Aif expression. We demonstrate that activated CD4 + and CD8 + peripheral T cells from Hq mice show resistance to neglect-induced death (NID) triggered by growth factor withdrawal, but not to death induced by multiple agents that trigger DNA damage. Aif translocates to the nucleus in cells undergoing NID, and, in Hq T cell blasts, resistance to NID is associated with reduced cytosolic release of mitochondrial cytochrome c, implicating Aif in this event. In contrast, Hq T cell blasts express higher levels of CD95L, demonstrating increased susceptibility to activation-induced cell death (AICD) and apoptosis triggered by hydrogen peroxide. Superoxide scavenging protects from AICD in wild-type, but not Hq, T cell blasts, suggesting that Aif plays a crucial superoxide-scavenging role to regulate T cell AICD. Finally, the altered pattern of death susceptibility is reproduced by siRNA-mediated reduction of Aif expression in normal T cells. Thus, Aif serves nonredundant roles, both proapoptotic and antiapoptotic, in activated peripheral T cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | Srivastava, Smita; Banerjee, Hridesh; Chaudhry, Ashutosh; Khare, Anupriya; Sarin, Apurva; George, Anna; Bal, Vineeta; Durdik, Jeannine M.; Rath, Satyajit (2007) Apoptosis-inducing factor regulates death in peripheral T cells The Journal of Immunology, 179 (2). pp. 797-803. ISSN 0022-1767 |
| الاتاحة: | http://repository.ias.ac.in/62140/ http://www.jimmunol.org/content/179/2/797.abstract |
| رقم الانضمام: | edsbas.A2795C3D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |