Academic Journal
Novel Prognostic Scoring System after Surgery for Klatskin Tumor
| العنوان: | Novel Prognostic Scoring System after Surgery for Klatskin Tumor |
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| المؤلفون: | Kaiser, Gernot M., Paul, Andreas, Sgourakis, George, Molmenti, Ernesto P., DechÊNe, Alexander, Trarbach, Tanja, Stuschke, Martin, Baba, Hideo A., Gerken, Guido, Sotiropoulos, Georgios C. |
| المصدر: | The American Surgeon™ ; volume 79, issue 1, page 90-95 ; ISSN 0003-1348 1555-9823 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2013 |
| الوصف: | Klatskin tumor is a rare hepatobiliary malignancy whose outcome and prognostic factors are not clearly documented. Between April 1998 and January 2007, 96 patients with hilar cholangiocarcinoma underwent resection. Data were collected prospectively. Thirty-one variables were evaluated for prognostic significance. There were 40 trisectionectomies, 40 hemihepatectomies, five central hepatectomies, and 11 biliary hilar resections. Thirty-seven (n = 37) patients required vascular reconstruction. There were 68 R0, 26 R1, and two R2 resections. Age ( P = 0.048), pT status ( P = 0.046), R class ( P = 0.034), and adjuvant chemoradiation ( P = 0.045) showed predictive significance by multivariate Cox proportional hazard regression analysis. A point scoring system was determined as follows: age younger than 62 years:age 62 years or older = 1:2 points; pT1:pT2 to 4 = 1:2 points; R0:R1/2 = 1:2 points; and chemoradiation yes:no = 1:2 points. The only model that reached statistical significance ( P = 0.0332) described the following three groups: score 6 or less; score = 7; and score = 8. Median survival for score 6 or less, score = 7, and score = 8 was 26.5, 12, and 2.2 months, respectively ( P = 0.032). The corresponding 1- and 3-year survival rates were 73 to 56 per cent, 52 to 38 per cent, and 17 to 0 per cent, respectively. We propose a scoring system predictive of long-term surgical outcome that could potentially improve patient selection for further postoperative oncologic treatment for Klatskin tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/000313481307900136 |
| الاتاحة: | https://doi.org/10.1177/000313481307900136 https://journals.sagepub.com/doi/pdf/10.1177/000313481307900136 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.A265FD41 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/000313481307900136 |
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