Academic Journal
Early life predictors of obstructive sleep apnoea in young adults: Insights from a longitudinal community cohort (Raine study)
| العنوان: | Early life predictors of obstructive sleep apnoea in young adults: Insights from a longitudinal community cohort (Raine study) |
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| المؤلفون: | Ohn, Mon, McArdle, Nigel, Khan, R. Nazim, von Ungern-Sternberg, Britta S., Eastwood, Peter R., Walsh, Jennifer H., Wilson, Andrew C., Maddison, Kathleen J. |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | OSA, Early-life predictors, Young adult, Maternal health, Raine study |
| الوصف: | Objective ; Early-life obstructive sleep apnoea (OSA) predictors are unavailable for young adults. This study identifies early-life factors predisposing young adults to OSA. ; Methods ; This retrospective study included 923 young adults and their mothers from the Western Australian Pregnancy Raine Study Cohort. OSA at 22 years was determined from in-laboratory polysomnography. Logistic regression was used to identify maternal and neonatal factors associated with OSA in young adulthood. ; Results ; OSA was observed in 20.8% (192) participants. Maternal predictors of OSA included gestational diabetes mellitus (odds ratio (OR) 9.54, 95% confidence interval (CI) 1.7, 58.5, P = 0.011), preterm delivery (OR 3.18, 95%CI 1.1,10.5, P = 0.043), preeclampsia (OR 2.95, 95%CI 1.1,8.0, P = 0.034), premature rupture of membranes (OR 2.46, 95%CI 1.2, 5.2, P = 0.015), age ≥35 years (OR 2.28, 95%CI 1.2,4.4, P = 0.011), overweight and obesity (pregnancy BMI≥25 kg/m2) (OR 2.00, 95%CI 1.2,3.2, P = 0.004), pregnancy-induced hypertension (OR 1.89, 95%CI 1.1,3.2, P = 0.019), and Chinese ethnicity (OR 2.36,95%CI 1.01,5.5, P = 0.047). Neonatal predictors included male child (OR 2.10, 95%CI 1.5,3.0, P < 0.0001), presence of meconium-stained liquor during delivery (OR 1.60, 95%CI 1.0,2.5, P = 0.044) and admission to special care nursery (OR 1.51 95%CI 1.0,2.2, P = 0.040). Higher birth lengths reduced OSA odds by 7% for each centimetre (OR 0.93, 95%CI 0.87, 0.99, P = 0.033). ; Conclusions ; A range of maternal and neonatal factors predict OSA in young adults, including those related to poor maternal metabolic health, high-risk pregnancy and stressful perinatal events. This information could assist in the early identification and management of at-risk individuals and indicates that better maternal health may reduce the likelihood of young adults developing OSA. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| ردمك: | 978-0-01-052995-1 0-01-052995-0 |
| تدمد: | 1389-9457 1878-5506 |
| Relation: | ispartof: Sleep medicine spage 76 epage 81 vol 110; WOS:001052995000001; 991005594402707891; https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Early-life-predictors-of-obstructive-sleep/991005594402707891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12145979370007891/13149537880007891; alma:61MUN_INST/bibs/991005594402707891 |
| DOI: | 10.1016/j.sleep.2023.07.032 |
| الاتاحة: | https://doi.org/10.1016/j.sleep.2023.07.032 https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Early-life-predictors-of-obstructive-sleep/991005594402707891 https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12145979370007891/13149537880007891 |
| Rights: | © 2023 The Authors ; Open ; CC BY-NC V4.0 |
| رقم الانضمام: | edsbas.A23F1C0B |
| قاعدة البيانات: | BASE |
| ردمك: | 9780010529951 0010529950 |
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| تدمد: | 13899457 18785506 |
| DOI: | 10.1016/j.sleep.2023.07.032 |