Academic Journal
Costunosides A-C: cytotoxic sesquiterpene lactones from the rhizomes of Aucklandia costus Falc.
| العنوان: | Costunosides A-C: cytotoxic sesquiterpene lactones from the rhizomes of Aucklandia costus Falc. |
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| المؤلفون: | Anil Bhushan, Dixhya Rani, Bashir A. Lone, Misbah Tabassum, Ajai P. Gupta, Dilip M. Mondhe, Sumeet Gairola, Prem Narayan Gupta, Prasoon Gupta |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Pharmacology, Ecology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Aucklandia costus, cytotoxic, sesquiterpenes, AChE, BChE |
| الوصف: | Three new eudesmane type rare sesquiterpene lactone galactosides, costunosides A-C ( 1-3) were isolated from the rhizomes of Aucklandia costus along with ten known compounds ( 4-13 ). Costunosides A-C ( 1-3) are the first example of naturally eudesmane glycosides containing a β -galactopyranoside moiety. The structure and relative configurations of these compounds were established by comprehensive analysis of MS and, in particular 1D/2D NMR spectroscopic data. The isolated compounds were tested against a panel of human cancer cell lines, where compounds 3, 6 and 7 have shown promising cytotoxic activity against PC-3, HCT-116 and A549 cell lines with IC 50 values in the range of 3.4 µM to 9.3 µM, respectively. Costunosides A-C ( 1-3) were also screened for inhibition assay of acetyl-cholinesterase (AChE), and butyrylcholinesterase (BChE) and found inactive at a concentration of 10 µM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Costunosides_A-C_cytotoxic_sesquiterpene_lactones_from_the_rhizomes_of_i_Aucklandia_costus_i_Falc_/24515217 |
| DOI: | 10.6084/m9.figshare.24515217.v1 |
| الاتاحة: | https://doi.org/10.6084/m9.figshare.24515217.v1 https://figshare.com/articles/journal_contribution/Costunosides_A-C_cytotoxic_sesquiterpene_lactones_from_the_rhizomes_of_i_Aucklandia_costus_i_Falc_/24515217 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.A202BD49 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.24515217.v1 |
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