التفاصيل البيبلوغرافية
| العنوان: |
High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin |
| المؤلفون: |
Samuel Odarkwei Blankson, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Tornyigah, Rafiou Adamou, Azizath Moussiliou, Caroline Padounou, Annick Amoussou, Benedicta Ayiedu Mensah, Maroufou J. Alao, Gordon Awandare, Nicaise Tuikue Ndam, Christian Roussilhon, Rachida Tahar |
| المصدر: |
Diagnostics; Volume 13; Issue 3; Pages: 528 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
neopterin, severe malaria, cerebral malaria, anemia, Plasmodium falciparum, Benin |
| الوصف: |
Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of Beninese children with severe malaria. We evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease. Our results show that neopterin levels were not significantly different between patients with different forms of severe malaria, including severe non-cerebral malaria (SNCM) and cerebral malaria (CM). However, the levels of this molecule were found to be higher in patients with severe malarial anemia (SMA) among both CM and SNCM cases (p-value = 0.02). Additionally, the levels of this molecule were found to be higher in patients who died from these pathologies compared to those who survived among the two clinical groups (p-value < 0.0001) and within the same group (p-value < 0.0001 for the CM group, p-value = 0.0046 for the SNCM group). The AUC-ROC for fatality among all the severe cases was 0.77 with a 95%CI of (0.69–0.85). These results suggest that plasma neopterin levels constitute a potential biomarker for predicting fatality among severe falciparum malaria patients. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Diagnostic Microbiology and Infectious Disease; https://dx.doi.org/10.3390/diagnostics13030528 |
| DOI: |
10.3390/diagnostics13030528 |
| الاتاحة: |
https://doi.org/10.3390/diagnostics13030528 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.A2014CA4 |
| قاعدة البيانات: |
BASE |