Academic Journal
Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide
| العنوان: | Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide |
|---|---|
| المؤلفون: | Mikhaïl A. Van Herck, Luisa Vonghia, Sven M. Francque |
| المصدر: | Nutrients, Vol 9, Iss 10, p 1072 (2017) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, animal model, mouse, rat, hepatocellular carcinoma, high-fat diet, fibrosis, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the increasing incidence of obesity and diabetes in many Western countries, reaching a prevalence of up to 30% in the general population. Animal models have played a vital role in elucidating the pathophysiological mechanisms of NAFLD and continue to do so. A myriad of different models exists, each with its advantages and disadvantages. This review presents a brief overview of these models with a particular focus on the basic mechanisms and physical, biochemical and histological phenotype. Both nutritional and chemically induced, as well as genetic models are examined, including models combining different approaches. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://www.mdpi.com/2072-6643/9/10/1072; https://doaj.org/toc/2072-6643; https://doaj.org/article/78d62667b465468e9b95b4d4838ef3ee |
| DOI: | 10.3390/nu9101072 |
| الاتاحة: | https://doi.org/10.3390/nu9101072 https://doaj.org/article/78d62667b465468e9b95b4d4838ef3ee |
| رقم الانضمام: | edsbas.A1E46B35 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu9101072 |
|---|