التفاصيل البيبلوغرافية
| العنوان: |
In utero exposure to maternal hyperglycemia impacts the offspring's plasma metabolome/lipidome in the short term and its energy homeostasis in the long term, depending on the composition of the maternal milk received during lactation. ; L’exposition in utero à l’hyperglycémie maternelle impacte le métabolome/lipidome plasmatique de la descendance à court terme et son homéostasie énergétique à long terme selon la composition du lait maternel reçu pendant la période d’allaitement. |
| المؤلفون: |
Paul, Bobin, Blandine, Castellano, Lefebvre, Amandine, Grit, Isabelle, I., Agnès, David-Sochard, Mathilde, Gourdel, Mikaël, Croyal, Le Dréan, Gwenola, Marie-cécile-Alexandre-Gouabau, Marie-Cécile |
| المساهمون: |
Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Structure fédérative de recherche François Bonamy (Nantes Univ - SFR François Bonamy), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université (Nantes Univ), ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), JFN, ANR-22-CE17-0039,GDM-MILK,Le lait maternel un nouveau paradigme pour préserver la descendance née de mère ayant développé un diabète gestationnel de la mise en place ultérieure d'un diabète(2022) |
| المصدر: |
Journées Francophones de Nutrition ; https://hal.inrae.fr/hal-04390468 ; Journées Francophones de Nutrition, JFN, Dec 2023, Marseile, France |
| بيانات النشر: |
CCSD |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
[SDV]Life Sciences [q-bio] |
| جغرافية الموضوع: |
Marseile, France |
| الوصف: |
International audience ; Introduction and aim of the study: Gestational diabetes (GDM) is a major public health issue, affecting 1 in 6 pregnancies worldwide. GDM increases the offspring's risk of developing type 2 diabetes (T2D) in adulthood. Epidemiological studies show the benefits of breastfeeding duration on the child's glycemic status, but the long-term effects are still debated. Preliminary results suggest an adaptation of milk composition to maternal hyperglycemia. We therefore hypothesize that maternal hyperglycemia may modify the composition of milk in terms of key regulators of insulin sensitivity, with repercussions on the metabolism of the offspring. To test this hypothesis, cross-adoptions were performed in a nutritional model of DG rats. Material and methods: Female rats were fed a high-fat, high-sucrose diet (HFHS) or a standard diet (CTL) one week before and during 3 weeks' gestation. During the 3-week lactation period, the HFHS group was fed a standard diet (4HFHS) or maintained on HFHS (7HFHS). We calculated the area under the curve (AUC) and an insulin sensitivity index (ISIGutt) following oral glucose tolerance tests (OGTT) performed during gestation (G12) and lactation (L12). Milk composition was characterized on day 1 of lactation (L1), then at L8, L14 and L18 by targeted analysis of total fatty acid profiles (gas chromatography), or amino acid and sphingolipid concentrations and untargeted analyses of lipidomic profiles (liquid chromatography/tandem mass spectrometry). Plasma lipidome/metabolome phenotyping of newborn pups (D0) was performed using Biocrates' MxP500 quant kit on the Sciex QTRAP 6500+. Then, following cross-adoptions with normoglycemic or hyperglycemic dams, postnatal monitoring of offspring was carried out. Insulin sensitivity of adult offspring was measured (hyperinsulinemic euglycemic clamps), as well as insulin secretion capacity (OGTT) in response to a hypercaloric challenge from D120 to D220. Résultats et Analyses statistiques : A G12, les mères HFHS présentaient des ... |
| نوع الوثيقة: |
conference object |
| اللغة: |
French |
| الاتاحة: |
https://hal.inrae.fr/hal-04390468 |
| رقم الانضمام: |
edsbas.A1D9CA7A |
| قاعدة البيانات: |
BASE |