Academic Journal
Neurodevelopmental outcome in complicated twin pregnancy: prospective observational study
| العنوان: | Neurodevelopmental outcome in complicated twin pregnancy: prospective observational study |
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| المؤلفون: | Prasad, S, Beg, S, Badran, D, Masciullo, L, Huddy, C, Khalil, A |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | St George's University of London: Repository |
| الوصف: | OBJECTIVE: Twin pregnancies are associated with increased perinatal mortality and morbidity, but long-term neurodevelopmental outcomes remain under-investigated. The primary objective was to investigate the incidence of adverse neurodevelopment after one year of age in complicated monochorionic diamniotic (MCDA) twin pregnancies compared with uncomplicated twin pregnancies. METHODS: This was a prospective cohort study conducted at St George's University Hospital NHS Foundation Trust, London. Women with twin pregnancies culminating in at least one child surviving to at least 12 months up to 60 months (corrected for prematurity) at the time of assessment, were invited to complete the relevant Ages and Stages Questionnaires® test version 3 (ASQ-3). The two study groups were (1) complicated MCDA twin pregnancies and uncomplicated twin pregnancies (dichorionic and MCDA). Complicated twin pregnancies included those with twin-to-twin transfusion syndrome (TTTS), Twin Anaemia Polycythaemia Sequence (TAPS), selective Fetal Growth Restriction (sFGR), Twin Reversed Arterial Perfusion (TRAP) and single intrauterine demise (sIUD). The primary outcome measure was an abnormal ASQ-3 score, defined as a score of 2 standard deviations below the mean, for any one domain. Mixed-effects multivariable logistic regression was performed to determine whether a complicated MCDA twin pregnancy was independently associated with an abnormal ASQ-3 score. All analyses were performed using R v4.0 (R Foundation for Statistical Computing, Vienna, Austria) RESULTS: The study included 174 parents who completed the questionnaires, and therefore, 327 ASQ-3 questionnaires were available for analysis. Of those, 117/327 (35.8%) were classified as cases and 210/327 (64.2%) as controls. The overall incidence of an abnormal ASQ-3 score in children with complicated MCDA twin pregnancies was nearly double that in uncomplicated MCDA/DCDA twin pregnancies (14.5% versus 7.6%, p=0.056). Children born of complicated MCDA twin pregnancies showed significantly ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| Relation: | https://openaccess.sgul.ac.uk/id/eprint/115697/6/Ultrasound%20in%20Obstet%20%20%20Gyne%20-%202023%20-%20Prasad%20-%20Neurodevelopmental%20outcome%20in%20complicated%20twin%20pregnancy%20%20prospective.pdf; https://openaccess.sgul.ac.uk/id/eprint/115697/11/uog27448-sup-0001-tables.docx; https://openaccess.sgul.ac.uk/id/eprint/115697/1/Ultrasound%20in%20Obstet%20%20%20Gyne%20-%202023%20-%20Prasad.pdf; Prasad, S; Beg, S; Badran, D; Masciullo, L; Huddy, C; Khalil, A (2024) Neurodevelopmental outcome in complicated twin pregnancy: prospective observational study. Ultrasound Obstet Gynecol, 63 (2). pp. 189-197. ISSN 1469-0705 https://doi.org/10.1002/uog.27448 SGUL Authors: Khalil, Asma |
| DOI: | 10.1002/uog.27448 |
| الاتاحة: | https://openaccess.sgul.ac.uk/id/eprint/115697/ https://openaccess.sgul.ac.uk/id/eprint/115697/6/Ultrasound%20in%20Obstet%20%20%20Gyne%20-%202023%20-%20Prasad%20-%20Neurodevelopmental%20outcome%20in%20complicated%20twin%20pregnancy%20%20prospective.pdf https://openaccess.sgul.ac.uk/id/eprint/115697/11/uog27448-sup-0001-tables.docx https://openaccess.sgul.ac.uk/id/eprint/115697/1/Ultrasound%20in%20Obstet%20%20%20Gyne%20-%202023%20-%20Prasad.pdf https://doi.org/10.1002/uog.27448 |
| Rights: | cc_by_nc_4 |
| رقم الانضمام: | edsbas.A1D18B09 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/uog.27448 |
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