Academic Journal
Pollutants: a candidate as a new risk factor for osteoarthritis—results from a systematic literature review
| العنوان: | Pollutants: a candidate as a new risk factor for osteoarthritis—results from a systematic literature review |
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| المؤلفون: | Deprouw, Camille, Courties, Alice, Fini, Jean-Baptiste, Clerget-Froidevaux, Marie-Stéphanie, Demeneix, Barbara, Berenbaum, Francis, Sellam, Jérémie, Louati, Karine |
| المساهمون: | CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Physiologie moléculaire et adaptation (PhyMA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | EISSN: 2056-5933 ; RMD Open ; https://hal.science/hal-03919590 ; RMD Open, 2022, 8 (2), pp.e001983. ⟨10.1136/rmdopen-2021-001983⟩ |
| بيانات النشر: | HAL CCSD BMJ Publishing Group |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review (SLR) was performed to summarise existing knowledge on associations between OA and pollutants. Methods PubMed was used to identify studies reporting data on OA and pollutants in humans (examples of MeSH terms: “Pesticides” or “Polychlorinated Biphenyls” or ‘Lead’). Reports included epidemiological clinical studies, pollutant assessments in ex vivo OA joint, and in vitro effects of pollutants on chondrocytes. Results Among the 193 potentially relevant articles, 14 were selected and combined with 9 articles obtained by manual search. Among these 23 articles there were: (1) 11 epidemiological studies on the relationship between OA and pollutants exposure, (2) 8 on pollutant concentrations in ex vivo OA joint, (3) 4 on the in vitro effects of pollutants on human chondrocytes. Epidemiological studies investigating mainly chlorinated and fluorinated pollutants suggested a possible link with OA. In cross-sectional studies, radiographic knee OA prevalence increased with higher serum lead levels. There was also a relationship between serum lead levels and serum/urine joint biomarkers. A high concentration of heavy metals in the cartilage tidemark was found in ex vivo joints. In vitro, the viability of chondrocytes was reduced in presence of some pollutants. However, the level of knowledge currently remains low, justifying the need for new methodologically sound studies. Conclusions This SLR supports the hypothesis of a possible involvement of pollutants in OA disease risk. Large-scale epidemiological and biological studies and ideally big-data analysis are needed to confirm that pollutants could be risk factors for OA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03919590; https://hal.science/hal-03919590; https://hal.science/hal-03919590/document; https://hal.science/hal-03919590/file/Deprouw%20et%20al%202022.pdf |
| DOI: | 10.1136/rmdopen-2021-001983 |
| الاتاحة: | https://hal.science/hal-03919590 https://hal.science/hal-03919590/document https://hal.science/hal-03919590/file/Deprouw%20et%20al%202022.pdf https://doi.org/10.1136/rmdopen-2021-001983 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A1C1EBC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/rmdopen-2021-001983 |
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