Academic Journal
Journal of Ophthalmology / Relationship between neovascular density in swept source-optical coherence tomography angiography and signs of activity in exudative age-related macular degeneration
| العنوان: | Journal of Ophthalmology / Relationship between neovascular density in swept source-optical coherence tomography angiography and signs of activity in exudative age-related macular degeneration |
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| المؤلفون: | Ansari-Shahrezaei, Siamak, Stattin, Martin, Forster, Julia, Daniel, Ahmed, Graf, Alexandra, Krepler, Katharina |
| بيانات النشر: | Hindawi |
| سنة النشر: | 2019 |
| المجموعة: | MedUni Vienna ePub (Medzinische Universität Wien) |
| جغرافية الموضوع: | UMW:14533 |
| الوصف: | Purpose. To assess the relationship between signs of activity in exudative neovascular age-related macular degeneration (nAMD) following anti-vascular endothelial growth factor (anti-VEGF) treatment and morphology of choroidal neovascularization (CNV) based on neovascular density as imaged using swept source-optical coherence tomography angiography (SS-OCTA) in a qualitative manner. Methods. A single-cohort retrospective data analysis from one tertiary eye care center. Seventy-seven eyes of 72 patients were included and their charts reviewed which had been started on intravitreal injections with anti-VEGF for nAMD at least one year prior to enrollment. Clinically active disease was evaluated by slit-lamp fundus examination and spectral domain-OCT B-scans. Morphological appearance in SS-OCTA was characterized based on 5 different criteria and subsequently divided into 3 groups: predominantly hyperdense, minimally hyperdense, and hypodense lesions. Results. Fifty-eight eyes (75%) were considered clinically active and 19 eyes (25%) clinically inactive. CNV was depicted in 71 eyes (92%) by SS-OCTA and separated accordingly into predominantly hyperdense (32%), minimally hyperdense (34%), and hypodense lesions (34%). A borderline significant difference in the probability of neovascular activity for predominantly hyperdense lesions compared to hypodense lesions was detected (). Conclusions. Hyperdense choroidal neovascularization based on qualitative assessment of flow density showed a significant relation to active disease. Inactivity could not be matched adequately. This study demonstrated the potential usefulness of SS-OCTA for guidance of treatment in age-related macular degeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 2090-0058 |
| Relation: | vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-39623/128; urn:nbn:at:at-ubmuw:3-39623; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-39623; local:99145986886703331; system:AC16185815 |
| DOI: | 10.1155/2019/4806061 |
| الاتاحة: | https://doi.org/10.1155/2019/4806061 https://repositorium.meduniwien.ac.at/doi/10.1155/2019/4806061 https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-39623 |
| Rights: | cc-by_4 |
| رقم الانضمام: | edsbas.A199AB9E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20900058 |
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| DOI: | 10.1155/2019/4806061 |