Academic Journal
Effect of neocuproine, a selective Cu(I) chelator, on nitrergic relaxations in the mouse corpus cavernosum
| العنوان: | Effect of neocuproine, a selective Cu(I) chelator, on nitrergic relaxations in the mouse corpus cavernosum |
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| المؤلفون: | Göçmen C., Göktürk H.S., Ertug P.U., Önder S., Dikmen A., Baysal F. |
| المساهمون: | Çukurova Üniversitesi |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Bathocuproine, Corpus cavernosum, Neocuproine, Nitrergic relaxation, Non- adrenergic non-cholinergic (NANC) nerve, S-Nitrosoglutathione |
| الوصف: | PubMedID: 11020493 ; The effects of neocuproine and bathocuproine, Cu(I) and Cu(II) chelators, respectively, were studied on relaxations in response to electrical field stimulation, acetylcholine, S-nitrosoglutathione, acidified sodium nitrite and sodium nitroprusside in the mouse corpus cavernosum precontracted with phenylephrine. Neocuproine significantly inhibited relaxations induced by electrical field stimulation, acetylcholine and S- nitrosoglutathione, but not by acidified sodium nitrite and sodium nitroprusside. The pre-prepared neocuproine-Cu(I) complex was ineffective on the responses. The discrepancy between the shape of relaxations in response to electrical field stimulation or to acetylcholine and S-nitrosoglutathione was abolished by adding CuCl2 into the bathing medium. The copper action was blocked by neocuproine but not by bathocuproine. However, the pre-prepared bathocuproine-Cu(II) complex did not accelerate the relaxations affected by CuCl2. These findings suggest that a Cu(I)-dependent mechanism may play a role in the relaxation induced by the endogenous relaxant factor as well as by S-nitrosoglutathione in mouse cavernosal tissue. (C) 2000 Elsevier Science B.V. ; TF-99-8 Wageningen University and Research Centre ; This work was supported by the Çukurova University Research Foundation (TF-99-8 We are indebted to Çukurova University Experimental Research Centre (TIPDAM) for the supply of mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0014-2999 |
| Relation: | European Journal of Pharmacology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1016/S0014-2999(00)00657-9; https://hdl.handle.net/20.500.12605/13756; 406; 293; 300 |
| DOI: | 10.1016/S0014-2999(00)00657-9 |
| الاتاحة: | https://hdl.handle.net/20.500.12605/13756 https://doi.org/10.1016/S0014-2999(00)00657-9 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.A1694BAA |
| قاعدة البيانات: | BASE |
| تدمد: | 00142999 |
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| DOI: | 10.1016/S0014-2999(00)00657-9 |