Academic Journal
Amino-acid change in the Epstein-Barr-virus zebra protein in undifferentiated nasopharyngeal carcinomas from Europe and North Africa
| العنوان: | Amino-acid change in the Epstein-Barr-virus zebra protein in undifferentiated nasopharyngeal carcinomas from Europe and North Africa |
|---|---|
| المؤلفون: | Virginie Grunewald, Mathilde Bonnet, Sylvie Boutin, Timothy Yip, Hechmi Louzir, Jean Marie Seigneurin, Martine Raphael, Robert Touitou, Dominique Martel Renoir, Chantal Cochet, Anne Durandy, Patrice Andre, W. Lau, Yi Zeng, Irene Joab, LEVRERO, Massimo |
| المساهمون: | Virginie, Grunewald, Mathilde, Bonnet, Sylvie, Boutin, Timothy, Yip, Hechmi, Louzir, Levrero, Massimo, Jean Marie, Seigneurin, Martine, Raphael, Robert, Touitou, Dominique Martel, Renoir, Chantal, Cochet, Anne, Durandy, Patrice, Andre, W., Lau, Yi, Zeng, Irene, Joab |
| بيانات النشر: | WILEY-LISS |
| سنة النشر: | 1998 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| الوصف: | Different Epstein-Barr-virus(EBV) variants were found to be associated with nasopharyngeal carcinoma (NPC). The type-C variant lacks the BamHI site between the BamHI WI* and I* regions and the type-f variant has an extra BamHI site in the BamHI F fragment. The BNLF1 gene (which encodes the LMPI protein) from a nude-mouse-passaged CAO strain and from NPC biopsies from Taiwanese patients also exhibits variations resulting in structural and functional differences in the protein. The BZLF1 gene encodes the ZEBRA protein which triggers the EBV lytic cycle. A difference has been observed in 8 amino acids in the ZEBRA sequence in B95-8 (295) and P3HRI (ZP3) cell lines. EBV found in NPC biopsies and peripheral-blood cells from Asians was predominantly of the ZP3 type (72%), while 81% of samples from different EBV-associated diseases and peripheral-blood cells from North Africa or Europe were of the 295 type. We found that an alanine 206 had been replaced by a serine in the 295 sequence in 72% of the NPC biopsies from European and North African patients. The Zser206 variant is found in a significantly lower percentage (p < 0.001) of other EBV-positive tissues from individuals in the same region (10-33%). In contrast, a 30-bp deletion is observed near the 3' end of the LMPI gene in the majority of EBV (86%) from NPC and peripheral-blood cells from Asians, whereas a significantly lower percentage (p < 0.001) of NPC biopsies from European and North African patients (56%) have this deletion, as do lymphocytes from control individuals from the same region (36 and 55% respectively). (C) 1998 Wiley-Liss, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/9466647; info:eu-repo/semantics/altIdentifier/wos/WOS:000071797400002; volume:75; issue:4; firstpage:497; lastpage:503; numberofpages:7; journal:INTERNATIONAL JOURNAL OF CANCER; http://hdl.handle.net/11573/438561; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0032498631; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000071797400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a; http://www.scopus.com/inward/record.url?eid=2-s2.0-0032498631&partnerID=65&md5=789b59b3ad5c6b0c3f4563482fcbf3e9 |
| الاتاحة: | http://hdl.handle.net/11573/438561 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000071797400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a http://www.scopus.com/inward/record.url?eid=2-s2.0-0032498631&partnerID=65&md5=789b59b3ad5c6b0c3f4563482fcbf3e9 |
| رقم الانضمام: | edsbas.A11961DD |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |