Academic Journal
Heart rate variability is not suitable as a surrogate marker for pain intensity in patients with chronic pain
| العنوان: | Heart rate variability is not suitable as a surrogate marker for pain intensity in patients with chronic pain |
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| المؤلفون: | Moens, Maarten, Billet, Bart, MOLENBERGHS, Geert, De Smedt, Ann, Pilitsis, Julie G., De Vos, Ruben, Hanssens, Karel, Billot, Maxime, Roulaud, Manuel, Rigoard, Philippe, Goudman, Lisa |
| المساهمون: | Goudman, Lisa/0000-0002-2271-9855, Billot, Maxime/0000-0003-0979-2182, Moens, Maarten, Billet, Bart, MOLENBERGHS, Geert, De Smedt, Ann, Pilitsis, Julie G., De Vos, Ruben, Hanssens, Karel, Billot, Maxime, Roulaud, Manuel, Rigoard, Philippe, Goudman, Lisa |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS |
| سنة النشر: | 2023 |
| المجموعة: | Document Server@UHasselt (Universiteit Hasselt) |
| مصطلحات موضوعية: | Biomarker, Surrogacy, Chronic pain, Autonomic nervous system, Pain management |
| الوصف: | The search towards more objective outcome measurements and consequently surrogate markers for pain started decades ago; however, no generally accepted biomarker for pain has qualified yet. The goal is to explore the value of heart rate variability (HRV) as surrogate marker for pain intensity chronic pain setting. Pain intensity scores and HRV were collected in 366 patients with chronic pain, through a cross-sectional multicenter study. Pain intensity was measured with both the visual analogue scale and numeric rating scale, whereas 16 statistical HRV parameters were derived. Canonical correlation analysis was performed to evaluate the correlation between the dependent pain variables and the HRV parameters. Surrogacy was determined for each HRV parameter with point estimates between 0 and 1 whereby values close to 1 indicate a strong association between the surrogate and the true endpoint at the patient level. Weak correlations were revealed between HRV parameters and pain intensity scores. The highest surrogacy point estimate was found for mean heart rate as marker for average pain intensity on the numeric rating scale with point estimates of 0.0961 (95% confidence interval [CI] 0.0384-0.1537) and 0.0209 (95% CI 0-0.05) for patients without medication use and with medication, respectively. This study indicated that HRV parameters as separate entities are no suitable surrogacy candidates for pain intensity, in a population of chronic pain patients. Further potential surrogate candidates and clinical robust true endpoints should be explored, to find a surrogate measure for the highly individual pain experience. ; The authors thank Wendy Van Tiggel for her input during the initiation phase of the study, and Tine Casier, B ´en ´edicte Bertrem, Jolien Desutter, and Nieke Vets for their help with the data collection. No funding was obtained for this specific study. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | PAIN, 164 (8) , p. 1741 -1749; http://hdl.handle.net/1942/40783; 1749; 1741; 164; 001030779300011 |
| DOI: | 10.1097/j.pain.0000000000002868 |
| الاتاحة: | http://hdl.handle.net/1942/40783 https://doi.org/10.1097/j.pain.0000000000002868 |
| رقم الانضمام: | edsbas.A0EBA13E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/j.pain.0000000000002868 |
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