Academic Journal
Advances in the study of macrophage polarization in inflammatory immune skin diseases
| العنوان: | Advances in the study of macrophage polarization in inflammatory immune skin diseases |
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| المؤلفون: | Xia, Tingting, Fu, Shengping, Yang, Ruilin, Yang, Kang, Lei, Wei, Yang, Ying, Zhang, Qian, Zhao, Yujie, Yu, Jiang, Yu, Limei, Zhang, Tao |
| المصدر: | Journal of Inflammation ; volume 20, issue 1 ; ISSN 1476-9255 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type and the anti-inflammatory M2-type, both of which perform almost entirely opposing functions. Due to this characteristic, macrophages perform different functions at different stages of immunity and inflammation. Inflammatory immune skin diseases usually show an imbalance in the M1/M2 macrophage ratio, and altering the macrophage polarization phenotype can either make the symptoms worse or better. Therefore, this review presents the mechanisms of macrophage polarization, inflammation-related signaling pathways (JAK/STAT, NF-κB, and PI3K/Akt), and the role of both in inflammatory immune skin diseases (psoriasis, AD, SLE, BD, etc.) to provide new directions for basic and clinical research of related diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12950-023-00360-z |
| DOI: | 10.1186/s12950-023-00360-z.pdf |
| DOI: | 10.1186/s12950-023-00360-z/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12950-023-00360-z https://link.springer.com/content/pdf/10.1186/s12950-023-00360-z.pdf https://link.springer.com/article/10.1186/s12950-023-00360-z/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.A084290 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12950-023-00360-z |
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